1,4-二庚酰基哌嗪 | 18903-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,4-二庚酰基哌嗪
• 英文名称: Piperazine, 1,4-diheptanoyl-
• 英文别名: 1-(4-heptanoylpiperazin-1-yl)heptan-1-one
• CAS: 18903-10-1
• 化学式: C₁₈H₃₄N₂O₂
• 分子量: 310.5
• InChiKey: FEFHVXVBNCGEEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

文献信息

• Penetration enhancers for transdermal delivery of systemic agents
  申请人：RESEARCH TRIANGLE PHARMACEUTICALS LTD.

  公开号：EP0268222A2

  公开（公告）日：1988-05-25

  This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; Rʹ is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, wherein Rʺ is H or halogen, and salts, e.g. acid or quaternary derivatives, thereof. These compositions are useful in topical or transdermal applications of the physiologically-active agent.

  本发明涉及一种在透皮装置或制剂中通过人和动物的皮肤或粘膜施用全身活性剂（包括治疗剂）的方法，包括与所述全身活性剂一起局部施用有效量的膜渗透促进剂，其结构式为 其中 X 可以代表硫、氧或氮；a 和 b 可以是 0 或 1，c 可以是 0、1 或 2，但当 X 是氧时，a、b 和 c 是 0，当 X 是氮时，c 是 0，a 或 b 中只有一个是 1，当 X 是硫时，a 和 b 是 0；A 是具有 0 至 2 个双键的支链或直链二价脂族基；Rʹ 选自由 H、具有 1 至 4 个碳原子的低级烷基、苯基、低级烷基或卤素取代的苯基、乙酰氨基、卤素、哌啶基、低级烷基或卤素取代的哌啶基、碳烷氧基、羧酰胺和烷酰基组成的组；以及 R 是氢或具有 1 至 4 个碳原子的低级烷基、 其中 Rʺ 是氢或卤素，以及它们的盐，如酸或季衍生物。这些组合物可用于生理活性剂的局部或透皮应用。
• 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0582065A1

  公开（公告）日：1994-02-09

  This invention provides a process for the conversion of a reactant into a reaction product in the presence of an acid catalyst which comprises contacting said reactant with an acid catalyst comprising a compound represented by the general formula wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0,1 or 2, except that when X is oxygen, a, b and c are O, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, wherein R'' is H or halogen, and salts thereof, and Z is selected from the group consisting of anions of strong acids.

  本发明提供了一种在酸催化剂存在下将反应物转化为反应产物的工艺，该工艺包括将所述反应物与酸催化剂接触，酸催化剂由通式所代表的化合物组成。 其中 X 可以代表硫、氧或氮；a 和 b 可以是 0 或 1，c 可以是 0、1 或 2，但当 X 是氧时，a、b 和 c 是 O，当 X 是氮时，c 是 0，a 或 b 中只有一个是 1，当 X 是硫时，a 和 b 是 0；A 是支链或直链二价脂族基，具有 0 至 2 个双键；R'选自由 H、具有 1 至 4 个碳原子的低级烷基、苯基、低级烷基或卤素取代的苯基、乙酰氨基、卤素、哌啶基、低级烷基或卤素取代的哌啶基、碳烷氧基、羧酰胺和烷酰基组成的组；以及 R 为氢或具有 1 至 4 个碳原子的低级烷基、 其中 R''是氢或卤素，以及它们的盐，Z 选自强酸阴离子组成的组。
• COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0280703B1

  公开（公告）日：1993-12-29
• US4917896A
  申请人：——

  公开号：US4917896A

  公开（公告）日：1990-04-17
• US5073544A
  申请人：——

  公开号：US5073544A

  公开（公告）日：1991-12-17