1-(1-苄基哌啶-4-基)-5-氯-1H-苯并[d]咪唑-2(3h)-酮 | 185058-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(1-苄基哌啶-4-基)-5-氯-1H-苯并[d]咪唑-2(3h)-酮
• 英文名称: 1-(1-Benzyl-piperidin-4-yl)-5-chloro-1,3-dihydro-benzoimidazol-2-one
• 英文别名: 1-(1-Benzylpiperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one；3-(1-benzylpiperidin-4-yl)-6-chloro-1H-benzimidazol-2-one
• CAS: 185058-65-5
• 化学式: C₁₉H₂₀ClN₃O
• 分子量: 341.84
• InChiKey: SKPVLGLSJVUPFF-UHFFFAOYSA-N

物化性质

• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Signaling-biased mu opioid receptor agonists
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10751335B2

  公开（公告）日：2020-08-25

  The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.

  本发明提供的阿片受体激动剂是一种镇痛剂，与同等有效剂量的吗啡相比，副作用较小。没有或减轻的副作用包括以下一种或多种：便秘、呼吸抑制、耐受性、依赖性、恶心、精神错乱、镇静、低血压和治疗后戒断症状。
• DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE
  申请人：PFIZER INC.

  公开号：EP0828754A1

  公开（公告）日：1998-03-18
• SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20190055214A1

  公开（公告）日：2019-02-21

  The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.
• US5936089A
  申请人：——

  公开号：US5936089A

  公开（公告）日：1999-08-10
• [EN] DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE<br/>[FR] DIPEPTIDES FAVORISANT LA SECRETION DE L'HORMONE DE CROISSANCE
  申请人：PFIZER INC.

  公开号：WO1996038471A1

  公开（公告）日：1996-12-05

  (EN) Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.(FR) L'invention se rapporte aux composés de la formule (I). Il s'agit de mimétiques des peptides favorisant la secrétion de l'hormone de croissance, qui sont utiles pour le traitement et la prévention de l'ostéoporose.