1-(2,2,2-三氟乙磺酰)-哌啶-4-酮 | 1016263-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(2,2,2-三氟乙磺酰)-哌啶-4-酮
• 英文名称: 1-(2,2,2-trifluoroethanesulfonyl)-piperidin-4-one
• 英文别名: 1-(2,2,2-trifluoroethylsulfonyl)piperidin-4-one
• CAS: 1016263-67-4
• 化学式: C₇H₁₀F₃NO₃S
• 分子量: 245.223
• InChiKey: OWLCVHCSORFNRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  金刚烷酮 、 1-(2,2,2-三氟乙磺酰)-哌啶-4-酮 在 甲基三氧化铼(VII) 双氧水 、 tetrafluoroboric acid 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以51%的产率得到
  参考文献：
  名称：

  Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

  摘要：

  A rapid, two-step synthesis of a range of dispiro-1,2.4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability and to be superior to trioxane analogues in terms of both stability and activity. Selected analogues have in vitro nanomolar antimalarial activity and good oral activity and are nontoxic in screens for both cytotoxicity and genotoxicity. The synthesis of a fluorescent 7-nitrobenza-2-oxa-1,3-diazole (NBD) tagged tetraoxane probe and use of laser scanning confocal microscopy techniques have shown that tagged molecules accumulate selectively only in parasite infected erythrocytes and that intraparasitic formation of adducts could be inhibited by co-incubation with the iron chelator desferrioxamine (DFO).

  DOI：

  10.1021/jm701435h
• 作为产物：
  描述：

  2,2,2-三氟乙基磺酰氯 、 4-氧代哌啶酮盐酸盐 在 potassium carbonate 作用下， 以 氯仿 、 水 为溶剂， 以62%的产率得到1-(2,2,2-三氟乙磺酰)-哌啶-4-酮
  参考文献：
  名称：

  Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

  摘要：

  A rapid, two-step synthesis of a range of dispiro-1,2.4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability and to be superior to trioxane analogues in terms of both stability and activity. Selected analogues have in vitro nanomolar antimalarial activity and good oral activity and are nontoxic in screens for both cytotoxicity and genotoxicity. The synthesis of a fluorescent 7-nitrobenza-2-oxa-1,3-diazole (NBD) tagged tetraoxane probe and use of laser scanning confocal microscopy techniques have shown that tagged molecules accumulate selectively only in parasite infected erythrocytes and that intraparasitic formation of adducts could be inhibited by co-incubation with the iron chelator desferrioxamine (DFO).

  DOI：

  10.1021/jm701435h

文献信息

• DISPIRO TETRAOXANE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MALARIA AND/OR CANCER
  申请人：Amewu Richard

  公开号：US20100113436A1

  公开（公告）日：2010-05-06

  A compound having the formula (I) wherein ring A represents a substituted or unsubstituted monocyclic or multicyclic ring; m=any positive integer; n=0-5; X=CH and Y=—C(O)NR 1 R 2 , —NR 1 R 2 or —S(O) 2 R 4 , where R 1 , R 2 and R 4 are each individually selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring, or any combination thereof, or R 1 and R 2 are linked so as to form part of a substituted or unsubstituted heterocyclic ring, or X=N and Y=—S(O) 2 R 3 or —C(O)R 3 , where R 3 is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring or any combination thereof.

  化合物的式子为（I），其中环A代表取代或未取代的单环或多环环；m=任何正整数；n=0-5；X=CH，Y=—C（O）NR1R2，—NR1R2或—S（O）2R4，其中R1，R2和R4分别从H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的胺基，取代或未取代的碳环，取代或未取代的杂环，或任何这些的组合中单独选择，或R1和R2被连接起来形成取代或未取代的杂环的一部分，或X=N且Y=—S（O）2R3或—C（O）R3，其中R3从H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的胺基，取代或未取代的碳环，取代或未取代的杂环，或任何这些的组合中选择。
• DISPIRO TETRAOXANE COMPOUNDS
  申请人：Amewu Richard

  公开号：US20130023551A1

  公开（公告）日：2013-01-24

  A compound having the formula (I) wherein ring A represents a substituted or unsubstituted monocyclic or multicyclic ring; m=any positive integer; n=0-5; X═CH and Y═—C(O)NR 1 R 2 , —NR 1 R 2 or —S(O) 2 R 4 , where R 1 , R 2 and R 4 are each individually selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring, or any combination thereof, or R 1 and R 2 are linked so as to form part of a substituted or unsubstituted heterocyclic ring, or X═N and Y═—S(O) 2 R 3 or —C(O)R 3 , where R 3 is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring or any combination thereof.

  化合物的化学式为（I），其中环A代表取代或未取代的单环或多环环；m = 任何正整数；n = 0-5；X = CH，Y = -C（O）NR1R2，-NR1R2或-S（O）2R4，其中R1，R2和R4分别选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的胺基，取代或未取代的碳环，取代或未取代的杂环，或任何组合，或R1和R2连接成为取代或未取代的杂环的一部分；或X = N，Y = -S（O）2R3或-C（O）R3，其中R3选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的胺基，取代或未取代的碳环，取代或未取代的杂环或任何组合。
• DISPIRO TETRAOXANE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MALARIA AND/OR CANCER
  申请人：Liverpool School of Tropical Medicine

  公开号：EP2091935A2

  公开（公告）日：2009-08-26
• [EN] DISPIRO TETRAOXANE COMPOUNDS<br/>[FR] COMPOSÉS DISPIROTÉTRAOXANE
  申请人：UNIV LIVERPOOL

  公开号：WO2008038030A2

  公开（公告）日：2008-04-03

  [EN] A compound having the formula (I) wherein ring A represents a substituted or unsubstituted monocyclic or multicyclic ring; m=any positive integer; n=0-5; X=CH and Y=-C(O)NR¹R², -NR¹R² or -S(O)₂R⁴, where R¹, R² and R⁴ are each individually selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring, or any combination thereof, or R¹ and R² are linked so as to form part of a substituted or unsubstituted heterocyclic ring, or X=N and Y=-S(O)₂R³ or -C(O)R³, where R³ is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted amine, substituted or unsubstituted carbocyclic ring, substituted or unsubstituted heterocyclic ring or any combination thereof.
  [FR] L'invention concerne un composé répondant à la formule (I), dans laquelle le noyau A représente un noyau monocyclique ou polycyclique substitué ou non substitué; m = n'importe quel nombre entier positif; n = 0-5; X = CH et Y = -C(O)NR¹R², -NR¹R² ou -S(O)₂R⁴, où R¹, R² et R⁴ sont chacun individuellement sélectionnés dans le groupe constitué de H, d'alkyles substitués ou non substitués, d'aryles substitués ou non substitués, d'amines substituées ou non substituées, de noyaux carbocycliques substitués ou non substitués, de noyaux hétérocycliques substitués ou non substitués ou de n'importe quelle combinaison de ceux-ci ou bien R¹ et R² sont reliés de façon à former une partie d'un noyau hétérocyclique substitué ou non substitué ou bien X = N et Y = -S(O)₂R³ ou -C(O)R³, où R³ est sélectionné dans le groupe constitué de H, d'alkyles substitués ou non substitués, d'aryles substitués ou non substitués, d'amines substituées ou non substituées, de noyaux carbocycliques substitués ou non substitués, de noyaux hétérocycliques substitués ou non substitués ou de n'importe quelle combinaison de ceux-ci.
• Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles
  作者：Gemma L. Ellis、Richard Amewu、Sunil Sabbani、Paul A. Stocks、Alison Shone、Deborah Stanford、Peter Gibbons、Jill Davies、Livia Vivas、Sarah Charnaud、Emily Bongard、Charlotte Hall、Karen Rimmer、Sonia Lozanom、María Jesús、Domingo Gargallo、Stephen A. Ward、Paul M. O’Neill

  DOI：10.1021/jm701435h

  日期：2008.4.1

  A rapid, two-step synthesis of a range of dispiro-1,2.4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability and to be superior to trioxane analogues in terms of both stability and activity. Selected analogues have in vitro nanomolar antimalarial activity and good oral activity and are nontoxic in screens for both cytotoxicity and genotoxicity. The synthesis of a fluorescent 7-nitrobenza-2-oxa-1,3-diazole (NBD) tagged tetraoxane probe and use of laser scanning confocal microscopy techniques have shown that tagged molecules accumulate selectively only in parasite infected erythrocytes and that intraparasitic formation of adducts could be inhibited by co-incubation with the iron chelator desferrioxamine (DFO).