6'-(3-chloro-4-fluoro-phenyl)-4-(2,4-dimethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6'-(3-chloro-4-fluoro-phenyl)-4-(2,4-dimethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl
• 英文别名: 2-(3-Chloro-4-fluoro-phenyl)-6-[4-(2,4-dimethylphenyl)piperazin-1-yl]pyrazine；2-(3-chloro-4-fluorophenyl)-6-[4-(2,4-dimethylphenyl)piperazin-1-yl]pyrazine
• 化学式: C₂₂H₂₂ClFN₄
• 分子量: 396.895
• InChiKey: LWPJZYVTVWHJHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Polysulfone compositions exhibiting very low color and high light transmittance properties and articles made therefrom
  申请人：El-Hibri Mohammad Jamal

  公开号：US20050176923A1

  公开（公告）日：2005-08-11

  A polysulfone composition is provided having a total luminous light transmittance of 84 % or greater when measured on 0.1 inch thick specimens using ASTM D-1003. The specimens also meet at least one of the following two conditions: 1) a yellowness index (YI) of less than about 5.0 as measured according to ASTM D-1925 on 0.1 inch thick specimens, or 2) a color factor (CF) of less than about 25, wherein CF is defined by the following equation: CF=270[(x+y) sample −(x+y) air ]/t, wherein x and y are chromaticity coordinates measured in transmittance mode and t is sample thickness in inches. Another polysulfone composition is provided comprising a polysulfone, an organic phosphorous-containing melt stabilizer, and at least one of the following additives: a blue to violet dye, and an organic optical brightener. The polysulfone composition of the present invention is used to form transparent molded articles such as ophthalmic lenses.

  一种聚砜组合物在 0.1 英寸厚的试样上使用 ASTM D-1003 测量时，总透光率达到或超过 84%。试样还至少满足以下两个条件之一：1) 根据 ASTM D-1925 标准在 0.1 英寸厚的试样上测量，黄度指数 (YI) 小于约 5.0，或 2) 色度系数 (CF) 小于约 25，其中 CF 由以下公式定义：CF=270[(x+y) 样品 -（x+y） 空气 其中 x 和 y 是在透射模式下测量的色度坐标，t 是以英寸为单位的样品厚度。另一种聚砜组合物包含聚砜、有机含磷熔体稳定剂和至少一种以下添加剂：蓝紫色染料和有机 光学增白剂。本发明的聚砜组合物可用于制造透明的模塑物品，如眼科镜片。
• Pyrazine Derivatives As Effective Compounds Against Infectious Diseases
  申请人：Eikhoff Jan Eike

  公开号：US20080194574A1

  公开（公告）日：2008-08-14

  The present invention relates to pyrazine derivatives according to the general formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceutical compounds as well as the use of these compounds for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases, stroke and especially for the treatment of herpesviral induced infections, including opportunistic infections as well as infections and diseases caused by human cytomegalovirus (HCMV).
• US7423110B2
  申请人：——

  公开号：US7423110B2

  公开（公告）日：2008-09-09