1-(2-甲基丙基)哌啶 | 10315-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(2-甲基丙基)哌啶
• 英文名称: N-isobutylpiperidine
• 英文别名: 1-isobutyl-piperidine；1-Isobutyl-piperidin；1-(2-methylpropyl)-piperidine；1-Piperidino-2-methyl-propan；N-Isobutyl-piperidin；1-Isobutylpiperidin；Piperidine, 1-(2-methylpropyl)-；1-(2-methylpropyl)piperidine
• CAS: 10315-89-6
• 化学式: C₉H₁₉N
• mdl: MFCD16300766
• 分子量: 141.257
• InChiKey: BNBLWPUWMNURAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-甲基丙基)哌啶 以 四氯化碳 、 氢氟酸 为溶剂， 生成
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.2, page 148 - 180

  摘要：

  DOI：
• 作为产物：
  描述：

  1-异丁烯基哌啶 在 三(五氟苯基)硼烷 、 二苯基硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以99%的产率得到1-(2-甲基丙基)哌啶
  参考文献：
  名称：

  An efficient metal-free reduction using diphenylsilane with (tris–perfluorophenyl)borane as catalyst

  摘要：

  An efficient metal-free reduction of various C=X (X = O, N, C) bonds into their corresponding amines or hydrocarbons using the Ph2SiH2/B(C6F5)(3) catalytic system is demonstrated. This protocol reduces enamines, enol esters, carbonyls, amides, and isocyanates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.066

文献信息

• Catalytic Hydrogenation of Amides to Amines under Mild Conditions
  作者：Mario Stein、Bernhard Breit

  DOI：10.1002/anie.201207803

  日期：2013.2.18

  Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd–Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines.

  在（不是很大）压力下：已开发出一种使用双金属Pd-Re催化剂将叔酰胺和仲酰胺氢化成胺的通用方法，具有优异的选择性。反应在低压和较低温度下进行。该方法为有机化学家提供了一种简单可靠的胺合成工具。
• 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF
  申请人：Samumed, LLC

  公开号：US20140194441A1

  公开（公告）日：2014-07-10

  Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

  揭示了用于治疗各种疾病和病理的吲唑化合物。更具体地，本公开涉及使用吲唑化合物或其类似物治疗由Wnt途径信号激活所特征的疾病（例如癌症、异常细胞增殖、血管生成、阿尔茨海默病、肺部疾病和骨关节炎），调节由Wnt途径信号介导的细胞事件，以及由于Wnt途径和/或一个或多个Wnt信号组分的突变或失调而导致的遗传疾病和神经系统疾病/疾患/疾病。还提供了治疗与Wnt相关疾病状态的方法。
• BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20160333009A1

  公开（公告）日：2016-11-17

  The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDOL) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R 1 , R 2a , R 2b , R n , R m , and R t are as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.

  本公开提供了式I的吲哌酮2,3-二氧化酶1（IDOL）抑制剂： 或其药学上可接受的盐，其中X、L、n、m、R 1 、R 2a 、R 2b 、R n 、R m 和R t 如本文所定义，以及包括式I化合物的药物组合物，或其药学上可接受的盐，并使用这些方法来治疗由IDO1介导的疾病。
• 9-Aminocarbonylsubstituted derivatives of glycylcyclines
  申请人：Sum Phaik-Eng

  公开号：US20070049564A1

  公开（公告）日：2007-03-01

  This invention provides compounds of Formula I having the structure where R 1 , R 2 , R 3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R 4 , R 5 , R 6 and R 10 and A are defined in the specification are useful as chemical intermediates.

  这项发明提供了具有结构的化合物，其中R1、R2、R3和A在规范中定义，或其药用盐，可用作抗菌剂。根据公式（II）的化合物： 其中Q、R4、R5、R6和R10以及A在规范中定义，可用作化学中间体。
• Insecticidal Benzenedicarboxamide Derivative
  申请人：Wada Katsuaki

  公开号：US20110184188A1

  公开（公告）日：2011-07-28

  The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W 1 to W 9 , and R 1 to R 3 are as defined here-in.

  本发明涉及一种新型苯二甲酰胺衍生物及其作为杀虫剂的用途，其化学式为(I)，其中化学基团W1至W9，以及R1至R3如本文所定义。