1-(3-(甲基磺酰基)苯基)哌嗪盐酸盐 | 1352305-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(3-(甲基磺酰基)苯基)哌嗪盐酸盐
• 英文名称: 1-(3-methanesulfonylphenyl)piperazine hydrochloride
• 英文别名: 1-(3-(Methylsulfonyl)phenyl)piperazine hydrochloride；1-(3-methylsulfonylphenyl)piperazine;hydrochloride
• CAS: 1352305-13-5
• 化学式: C₁₁H₁₆N₂O₂S*ClH
• mdl: MFCD20921645
• 分子量: 276.787
• InChiKey: MLUWQKOMTQINGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.39
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲砜基苯胺 、 二(2-氯乙基)胺盐酸盐 以 环丁砜 为溶剂， 反应 14.0h， 以92%的产率得到1-(3-(甲基磺酰基)苯基)哌嗪盐酸盐
  参考文献：
  名称：

  An efficient scale up process for synthesis of N-arylpiperazines

  摘要：

  An efficient protocol for the synthesis of various substituted phenylpiperazines was developed using sulfolane as solvent. The protocol was clean, high yielding and products were obtained in high purities (>= 99%). It was also fast and convenient, as the final products were precipitated as hydrochloride salts and could be obtained by filtration. Sulfolane, an aprotic, dipolar, high boiling and recoverable solvent was used as a substitute for common organic solvents. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.06.003

文献信息

• An efficient scale up process for synthesis of N-arylpiperazines
  作者：Lokesh Ravilla、N. Venkata Subba Naidu、Kuppuswamy Nagarajan

  DOI：10.1016/j.tetlet.2015.06.003

  日期：2015.7

  An efficient protocol for the synthesis of various substituted phenylpiperazines was developed using sulfolane as solvent. The protocol was clean, high yielding and products were obtained in high purities (>= 99%). It was also fast and convenient, as the final products were precipitated as hydrochloride salts and could be obtained by filtration. Sulfolane, an aprotic, dipolar, high boiling and recoverable solvent was used as a substitute for common organic solvents. (C) 2015 Elsevier Ltd. All rights reserved.