1-(3-溴苯基)-N-甲基哌啶-4-胺 | 1184235-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(3-溴苯基)-N-甲基哌啶-4-胺
• 中文别名: 1-(3-溴苯基)-n-甲基哌啶-4-胺
• 英文名称: 1-(3-Bromophenyl)-N-methylpiperidin-4-amine
• CAS: 1184235-17-3
• 化学式: C₁₂H₁₇BrN₂
• 分子量: 269.18
• InChiKey: JERVZCCTEDZSJX-UHFFFAOYSA-N

物化性质

• 密度：
  1.36

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

文献信息

• BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3209664B1

  公开（公告）日：2020-06-03
• BICYCLIC HETEROARYL AMINE COMPOUNDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170355707A1

  公开（公告）日：2017-12-14

  Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q 1 is: (i) Cl, Br, I, —CN, —CH 3 , or —CF 3 ; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 R a and zero to 1 R b ; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R a , and R b are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.