1-(4-甲氧基丁基)哌嗪 | 496808-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(4-甲氧基丁基)哌嗪
• 英文名称: 1-(4-methoxybutyl)piperazine
• CAS: 496808-02-7
• 化学式: C₉H₂₀N₂O
• 分子量: 172.271
• InChiKey: RCUHJBWDIITPIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基丁基)哌嗪 、 N-(5-tert-butyl-2-methylphenyl)-2-chloro-7-methyl-7H-purin-6-amine 在 N,N-二异丙基乙胺 作用下， 以 异丙醇 为溶剂， 生成 N-(5-tert-butyl-2-methylphenyl)-2-[4-(4-methoxybutyl)piperazin-1-yl]-7-methyl-7H-purin-6-amine
  参考文献：
  名称：

  Purine derivatives as potent γ-secretase modulators

  摘要：

  The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-based gamma-secretase modulators with 300- to 2000-fold in vitro selectivity over inhibition of Notch cleavage and that selectively reduces A beta 42 in an APP-YAC transgenic mouse model. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.008

文献信息

• Catalyst system for the production of polyurethanes
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0144573A2

  公开（公告）日：1985-06-19

  A catalyst and process are provided for producing polyurethanes by contacting an organic polyol and an organic isocyanate with a catalyst comprising an N-substituted alkoxyalkyl piperazine and preferably additionally comprising an N-alkoxyalkyl morpholine wherein the alkylene moieties of the morpholine and piperazine are independently selected from the group consisting of C, to about C5 alkylene moieties, and wherein the alkoxy moieties are independently selected from the group consisting of C1 to about C3 alkoxy moieties.

  本发明提供了一种催化剂和工艺，通过将有机多元醇和有机异氰酸酯与催化剂接触生产聚氨酯，催化剂包括 N-取代烷氧基烷基哌嗪，最好还包括 N-烷氧基烷基吗啉，其中吗啉和哌嗪的亚烷基独立地选自 C 至约 C5 亚烷基组成的组，烷氧基独立地选自 C1 至约 C3 烷氧基组成的组。
• Chemical mechanical planarization for tungsten-containing substrates
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP2779217A2

  公开（公告）日：2014-09-17

  Chemical mechanical polishing (CMP) compositions for polishing tungsten or tungsten-containing substrates comprise an abrasive, at least one solid catalyst, a chemical additive selected from the groups consisting of piperazine derivatives, salts of cyanate, and combinations thereof; and a liquid carrier. Systems and processes use the aqueous formulations for polishing tungsten or tungsten-containing substrates.

  用于抛光钨或含钨基材的化学机械抛光（CMP）组合物包括磨料、至少一种固体催化剂、一种选自哌嗪衍生物、氰酸盐及其组合的化学添加剂；以及一种液体载体。系统和工艺使用水性制剂抛光钨或含钨基材。
• SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF
  申请人：Accutar Biotechnology Inc.

  公开号：EP3795570A1

  公开（公告）日：2021-03-24

  The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

  本公开涉及新型化合物、含有此类化合物的药物组合物及其在预防和治疗癌症及相关疾病和病症中的用途。在某些实施方案中，本文公开的化合物具有雄激素受体降解活性。
• Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
  申请人：Arvinas, Inc.

  公开号：US10723717B2

  公开（公告）日：2020-07-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作快速加速纤维肉瘤（RAF，如c-RAF、A-RAF和/或B-RAF；靶蛋白）的调节剂。特别是，本公开内容涉及双功能化合物，其一端含有与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、cereblon、抑制细胞凋亡蛋白或小鼠双敏同源物 2 配体，另一端含有与靶蛋白 RAF 结合的分子，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防由于靶蛋白的聚集或积聚或靶蛋白的组成性激活而导致的疾病或失调。
• TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1519915B1

  公开（公告）日：2009-05-27