1-O-{[1-甲基-5-(4-甲基苯甲酰)-1H-吡咯-2-基]乙酰基}-β-D-葡萄吡喃糖酮酸 | 136467-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-O-{[1-甲基-5-(4-甲基苯甲酰)-1H-吡咯-2-基]乙酰基}-β-D-葡萄吡喃糖酮酸
• 中文别名: 1,1'-(1,4-哌嗪二基)二乙醇
• 英文名称: 1-[4-(1-Hydroxyethyl)piperazin-1-yl]ethanol
• CAS: 136467-59-9
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.24
• InChiKey: XSXVRLKMAKDBSZ-UHFFFAOYSA-N

物化性质

• 沸点：
  275.9±35.0 °C(Predicted)
• 密度：
  1.125±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROCESS FOR PREPARING DI-, TRI- AND POLYAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232293A1

  公开（公告）日：2012-09-13

  Process for preparing primary amines which have at least one functional group of the formula (—CH 2 —NH 2 ) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH 2 —OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

  通过醇胺化起始物质制备至少具有一个功能基团（—CH2—NH2）和至少一个进一步的初级氨基基团的初级胺的过程，其中起始物质至少具有一个功能基团（—CH2—OH）和至少一个进一步的功能基团（—X），其中（—X）从羟基和初级氨基中选择，通过氨与水的消除，反应在至少包含来自周期表8、9和10族中选择的至少一个元素以及至少一个给体配体的至少一个复合催化剂的存在下均匀催化进行。
• PROCESS FOR THE PREPARATION OF PRIMARY AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232292A1

  公开（公告）日：2012-09-13

  Process for the preparation of primary amines which have at least one functional group of the formula (—CH 2 —NH 2 ) by alcohol amination of starting materials which have at least one functional group of the formula (—CH 2 —OH), with ammonia, with the elimination of water, where the alcohol amination is carried out under homogeneous catalysis in the presence of at least one complex catalyst which comprises at least one element selected from groups 8 and 9 of the Periodic Table of the Elements, and also at least one phosphorus donor ligand of the general formula (I).

  通过使用至少一个来自元素周期表第8和第9族的元素选定的至少一个元素组成的至少一个复合催化剂，在存在至少一个磷供体配体的情况下，在消除水的情况下，通过对至少一个具有式（—CH2—OH）的起始材料进行醇胺化，使用氨制备至少具有一个式（—CH2—NH2）的官能团的初级胺的方法。
• PROCESS FOR PREPARING ALKANOLAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232294A1

  公开（公告）日：2012-09-13

  Process for preparing alkanolamines which have a primary amino group (—NH 2 ) and a hydroxyl group (—OH) by alcohol amination of diols having two hydroxyl groups (—OH) by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

  通过使用氨和消除水的方式，通过醇胺化二醇制备具有一元氨基（—NH2）和一个羟基（—OH）的烷基胺的过程，其中反应在至少含有来自周期表第8、9和10族的至少一种元素以及至少一种给体配体的复合催化剂存在下均相催化进行。
• PROCESS FOR PREPARING 1,4-BISHYDROXYETHYLPIPERAZINE
  申请人：Wigbers Christof Wilhelm

  公开号：US20120108816A1

  公开（公告）日：2012-05-03

  Process for preparing 1,4-bishydroxyethylpiperazine (BHEPIP) of the formula I wherein diethanolamine (DEOA) of the formula II is reacted in the liquid phase in a reactor at a temperature in the range from 130 to 300° C. in the presence of a copper-comprising, chromium-free heterogeneous catalyst.

  制备1,4-双羟乙基哌嗪（BHEPIP）的过程如下：在液相反应器中，在温度范围为130至300°C的条件下，以及在存在铜基、无铬的非均相催化剂的情况下，将分子式为II的二乙醇胺（DEOA）与分子式为I的化合物反应。
• Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
  申请人：——

  公开号：US20040096506A1

  公开（公告）日：2004-05-20

  Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.

  生物可降解的聚酯类（ortho esters）可用作骨科植入物或从二噁烷基二（酮酸酯）中提供药物、化妆品和农业剂量的持续释放载体。这些生物可降解的聚酯类是由含有这些聚酯类的嵌段共聚物组成的。这些嵌段共聚物具有亲水和疏水的嵌段。它们在水溶液中形成胶束，适用于封装或溶解疏水或不溶于水的材料；它们还形成生物可降解的基质，用于持续释放活性成分。