6-Methyl-3-(4-methylpiperazin-1-yl)thiochromen-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-Methyl-3-(4-methylpiperazin-1-yl)thiochromen-4-one
• 化学式: C₁₅H₁₈N₂OS
• 分子量: 274.4
• InChiKey: OBRWAYIPVSRZFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  48.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods and materials for assessing chemotherapy responsiveness and treating cancer
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US10220016B2

  公开（公告）日：2019-03-05

  This document provides methods and materials involved in assessing chemotherapy responsiveness and treating cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) is likely to respond to chemotherapy (e.g., a taxane therapy) based at least in part on the presence of a variant in the mammal's polycystic kidney disease gene 1 (PKD1) are provided. In addition, methods and materials involved in treating mammals having cancer (e.g., breast cancer) by administering an inhibitor of ubiquitin specific peptidase 2 (USP2) polypeptide activity (e.g., NSC-632839, a 2-cyano-pyrimidine, or a 2-cyano-triazine) in combination with another chemotherapeutic agent such as a taxane therapy are provided.

  本文件提供了评估化疗反应性和治疗癌症（如乳腺癌）的方法和材料。例如，本文提供了至少部分基于哺乳动物多囊肾病基因 1（PKD1）变异的存在来确定癌症患者（如乳腺癌患者）是否可能对化疗（如紫杉类药物疗法）产生反应的方法和材料。此外，还提供了通过施用泛素特异性肽酶 2（USP2）多肽活性抑制剂（如 NSC-632839、2-氰基嘧啶或 2-氰基三嗪）与另一种化疗剂（如紫杉类疗法）联合治疗患有癌症（如乳腺癌）的哺乳动物的方法和材料。