4-(4-Ethylpiperazin-1-yl)-6,7-dimethoxyquinazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Ethylpiperazin-1-yl)-6,7-dimethoxyquinazoline
• 化学式: C₁₆H₂₂N₄O₂
• 分子量: 302.37
• InChiKey: BBAWUHWNRUBHGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PROTEIN KINASE INHIBITORS
  申请人：Hurley Laurence H.

  公开号：US20130302303A1

  公开（公告）日：2013-11-14

  Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R 1 , R 2 , R 3 , X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

  本发明揭示了具有在蛋白激酶介导的疾病和病症（如癌症）治疗中的用途的蛋白激酶抑制剂。本发明的化合物具有以下结构：包括立体异构体，前药和其药学上可接受的盐，其中A是从以下环基团中选择的环基团：其中R1、R2、R3、X、Z、L1、Cycl1、L2和Cycl2如本文所定义。本发明还揭示了含有本发明化合物的组合物，以及与其使用相关的方法。
• Protein Kinase Inhibitors
  申请人：Hurley Laurence H.

  公开号：US20110212929A1

  公开（公告）日：2011-09-01

  Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

  本发明揭示了具有治疗蛋白激酶介导疾病和病状（如癌症）功效的蛋白激酶抑制剂。本发明化合物具有以下结构，包括立体异构体、前药和药学上可接受的盐，其中A是从以下环基中选择的环基，而R1、R2、R3、X、Z、L1、Cycl1、L2和Cycl2的定义如下。此外，本发明还揭示了含有本发明化合物的组合物，以及与其使用相关的方法。
• US7312226B2
  申请人：——

  公开号：US7312226B2

  公开（公告）日：2007-12-25
• US7326713B2
  申请人：——

  公开号：US7326713B2

  公开（公告）日：2008-02-05
• US7335662B2
  申请人：——

  公开号：US7335662B2

  公开（公告）日：2008-02-26