1-{4-[(2-甲氧基乙基)氨基]-1-哌啶基}乙酮 | 849021-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-{4-[(2-甲氧基乙基)氨基]-1-哌啶基}乙酮
• 英文名称: 1-Acetyl-4-[(2-methoxyethyl)amino]piperidine
• 英文别名: 1-[4-(2-methoxyethylamino)piperidin-1-yl]ethanone
• CAS: 849021-41-6
• 化学式: C₁₀H₂₀N₂O₂
• mdl: MFCD03452783
• 分子量: 200.28
• InChiKey: RMJGIXARLGOLGM-UHFFFAOYSA-N

物化性质

• 沸点：
  92～97℃/0.1mm

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

文献信息

• TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND
  申请人：Medshine Discovery Inc.

  公开号：EP3848371A1

  公开（公告）日：2021-07-14

  Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

  公开了一系列三环呋喃取代的哌啶二酮化合物及其在制备治疗与 CRBN 蛋白质有关的疾病的药物中的应用。特别是公开了由式（I）代表的衍生物化合物或其药学上可接受的盐。
• TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS
  申请人：Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

  公开号：EP3848367A1

  公开（公告）日：2021-07-14

  The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.

  本发明公开了一系列三环化合物及其在制备治疗 CRBN 蛋白相关疾病的药物中的用途。具体而言，本发明公开了一种式（1）的衍生物化合物或其药学上可接受的盐。
• Tricyclic furan-substituted piperidinedione compound
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US11319330B2

  公开（公告）日：2022-05-03

  Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

  公开了一系列三环呋喃取代的哌啶二酮化合物及其在制备治疗与 CRBN 蛋白质有关的疾病的药物中的应用。特别是公开了由式（I）代表的衍生物化合物或其药学上可接受的盐。
• TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US20210317109A1

  公开（公告）日：2021-10-14

  Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.