1-氮杂双环[3.3.1]壬烷-5-甲酰氯 | 119103-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-氮杂双环[3.3.1]壬烷-5-甲酰氯
• 英文名称: 1-Azabicyclo[3.3.1]nonane-5-carbonyl chloride
• CAS: 119103-13-8
• 化学式: C₉H₁₄ClNO
• mdl: MFCD18806589
• 分子量: 187.66
• InChiKey: YKAVMHBKJQZFPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
  申请人：Chu Daniel

  公开号：US20090197863A1

  公开（公告）日：2009-08-06

  A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R 1 , R 2 , R 3 , and R 4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

  具有以下式(I)或式(II)所示结构的化合物： 其中变量Y，R1，R2，R3和R4如本文所定义。本文提供了聚(ADP-核糖)聚合酶活性的抑制剂。本文还描述了包括至少一种本文描述的化合物的药物组合物，以及使用本文描述的化合物或药物组合物治疗通过抑制PARP活性改善的疾病、疾病和症状。
• US8088760B2
  申请人：——

  公开号：US8088760B2

  公开（公告）日：2012-01-03
• [EN] BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)<br/>[FR] INHIBITEURS À BASE DE COMPOSÉS BENZOXAZOLE-CARBOXAMIDE DE L'ACTIVITÉ POLY(ADP-RIBOSE)POLYMÉRASE (PARP)
  申请人：LEAD THERAPEUTICS INC

  公开号：WO2009099736A2

  公开（公告）日：2009-08-13

  A compound having the structure set forth in Formula (I) or Formula (II): Formula (I) Formula (II) wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.