1-甲基-4-哌啶乙腈 | 164926-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-甲基-4-哌啶乙腈
• 中文别名: (1-甲基哌啶-4-基)乙腈；4-哌啶乙酰腈,1-甲基-(9CI)
• 英文名称: N-methyl-4-piperidinylacetonitrile
• 英文别名: (1-Methylpiperid-4-yl)acetonitrile；(1-Methylpiperidin-4-yl)acetonitrile；2-(1-methylpiperidin-4-yl)acetonitrile
• CAS: 164926-88-9
• 化学式: C₈H₁₄N₂
• mdl: MFCD13183904
• 分子量: 138.213
• InChiKey: DMJIGGBWHGOSQX-UHFFFAOYSA-N

物化性质

• 沸点：
  234.3±13.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  1-甲基-4-哌啶乙腈 在 盐酸 、 水 作用下， 反应 20.0h， 生成 1-甲基-4-哌啶乙酸
  参考文献：
  名称：

  INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

  摘要：

  本发明涉及3-二取代吲哚-2-酮衍生物，它们的制备方法以及它们的药用应用。

  公开号：

  US20100210662A1
• 作为产物：
  描述：

  (1-methyl-piperidin-4-ylidene)-acetonitrile 在 甲醇 、 magnesium 作用下， 生成 1-甲基-4-哌啶乙腈
  参考文献：
  名称：

  INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

  摘要：

  本发明涉及3-二取代吲哚-2-酮衍生物，它们的制备方法以及它们的药用应用。

  公开号：

  US20100210662A1

文献信息

• Thienopyrimidine and Thienopyridine Derivatives Substituted with Cyclic Amino Group
  申请人：Nakazato Atsuro

  公开号：US20070254898A1

  公开（公告）日：2007-11-01

  [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [Solution] A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  【待解决的问题】本发明的目的是提供一种针对CRF受体的拮抗剂，其作为治疗或预防代理，对CRF参与的疾病具有有效性，例如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合症、睡眠障碍、癫痫、皮炎、精神分裂症等。 【解决方案】一种噻唑嘧啶或噻唑吡啶衍生物，其被一个以下式[I]所代表的环状氨基团置换，具有高亲和力的CRF受体，对CRF参与的疾病具有有效性。
• Pyrrolopyrimidine Derivatives Substituted with Cyclic Amino Group
  申请人：NAKAZATO Atsuro

  公开号：US20080287397A1

  公开（公告）日：2008-11-20

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，作为治疗或预防与CRF有关的疾病的药物，例如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮炎、精神分裂症等。这个问题可以通过下式[I]所表示的带有环状氨基基团的吡咯吡嘧啶或吡咯吡啶衍生物来解决，其具有高亲和力，对CRF受体有效，并且对与CRF有关的疾病也有效。
• THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP
  申请人：Nakazato Atsuro

  公开号：US20090111835A1

  公开（公告）日：2009-04-30

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮炎、精神分裂症、疼痛等的治疗或预防剂。以下式[I]所代表的带有环状氨基团的噻唑嘧啶或噻唑啶衍生物具有高亲和力的CRF受体，对于CRF参与的疾病具有疗效。
• PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES
  申请人：Nakazato Atsuro

  公开号：US20110137031A1

  公开（公告）日：2011-06-09

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种针对CRF受体的拮抗剂，该拮抗剂可作为治疗或预防剂用于CRF参与的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮肤炎、精神分裂症、疼痛等。以下式[I]所示的带有氨基甲酰基取代的吡咯吡嘧啶或吡咯三嗪衍生物具有高亲和力，对于CRF参与的疾病具有有效作用。
• PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
  申请人：Deng Yongqi

  公开号：US20120114739A1

  公开（公告）日：2012-05-10

  The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

  本发明提供了使用吡唑并[1,5-a]嘧啶化合物抑制mTOR的方法以及使用这些化合物进行治疗、预防、抑制或改善与mTOR相关的一种或多种疾病的方法。