1-苯基哌啶-4-羧酸盐酸盐 | 209005-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-苯基哌啶-4-羧酸盐酸盐
• 英文名称: 1-phenylpiperidine-4-carboxylic acid hydrochloride
• 英文别名: 1-phenylpiperidine-4-carboxylic acid;hydrochloride
• CAS: 209005-67-4
• 化学式: C₁₂H₁₅NO₂*ClH
• 分子量: 241.718
• InChiKey: BEFZAPQHSZCXRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苯基哌啶-4-羧酸盐酸盐 在 potassium phosphate 、 XPhos Pd G2 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.5h， 生成 (S)-1-(5-chloro-2-methoxy-4-((2-methyl-3-(2-(1-phenylpiperidin-4-yl)benzo[d]oxazol-5-yl)benzyl)oxy)benzyl)piperidine-2-carboxylic acid
  参考文献：
  名称：

  [EN] COMPOUNDS USEFUL AS IMMUNOMODULATORS
  [FR] COMPOSÉS UTILES EN TANT QU'IMMUNOMODULATEURS

  摘要：

  本公开涉及通常用作免疫调节剂的化合物。本文提供了包含这些化合物的化合物、组合物以及它们的使用方法。该公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。

  公开号：

  WO2018118848A1

文献信息

• Aminopyrazole derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US06166038A1

  公开（公告）日：2000-12-26

  The present invention relates to a compound represented by the general formula [I]: ##STR1## wherein Ar.sup.1 represents an aryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl and lower haloalkyl groups; Ar.sup.2 represents an aryl or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aryl groups; R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl group; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom or a lower alkyl group, or R.sup.3 and R.sup.4 are linked to each other to form an alkylene group containing 2 to 4 carbon atoms which may have a lower alkyl group; and R.sup.5 represents a hydrogen atom or a lower alkyl or lower alkoxy group, or its salt, a method for its preparation as well as an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

  本发明涉及一种由通式[I]表示的化合物：##STR1## 其中，Ar.sup.1代表一个芳基基团，该基团可以具有来自卤素原子和较低的烷基和较低的卤代烷基组的取代基; Ar.sup.2代表一个芳基或杂环芳基基团，该基团可以具有来自卤素原子和较低的烷基，较低的烯基，较低的卤代烷基，较低的烷氧基，较低的烷硫基，较低的烷基氨基，较低的二烷基氨基和芳基基团的取代基; R.sup.1和R.sup.2可以相同也可以不同，每个代表氢原子或较低的烷基基团; R.sup.3和R.sup.4可以相同也可以不同，每个代表氢原子或较低的烷基基团，或者R.sup.3和R.sup.4彼此连接以形成一个含有2到4个碳原子的烷基基团，该基团可以具有较低的烷基基团; R.sup.5代表氢原子或较低的烷基或较低的烷氧基团，或其盐，以及作为活性成分的治疗暴食症、肥胖症或糖尿病的药剂。
• NOVEL AMINOPYRAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0945439A1

  公开（公告）日：1999-09-29

  The present invention relates to a compound represented by the general formula [I]: wherein Ar1 represents an aryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl and lower haloalkyl groups; Ar2 represents an aryl or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aryl groups; R1 and R2 may be the same or different and each represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and each represents a hydrogen atom or a lower alkyl group, or R3 and R4 are linked to each other to form an alkylene group containing 2 to 4 carbon atoms which may have a lower alkyl group; and R5 represents a hydrogen atom or a lower alkyl or lower alkoxy group, or its salt, a method for its preparation as well as an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

  本发明涉及通式[I]所代表的化合物： 其中Ar1代表芳基，其取代基可选自由卤素原子、低级烷基和低级卤代烷基组成的组；Ar2代表芳基或杂芳基，其取代基可选自由卤素原子、低级烷基、低级烯基、低级卤代烷基、低级烷氧基、低级烷硫基、低级烷氨基、低级二烷基氨基和芳基组成的组；R1 和 R2 可以相同或不同，各自代表一个氢原子或一个低级烷基；R3 和 R4 可以相同或不同，各自代表一个氢原子或一个低级烷基，或 R3 和 R4 相互连接形成一个含有 2 至 4 个碳原子的亚烷基，该亚烷基可能含有一个低级烷基；以及 R5 代表一个氢原子或一个低级烷基或低级烷氧基、 或其盐，其制备方法以及治疗贪食症、肥胖症或糖尿病的药物，其活性成分均包含该物质。
• Compounds useful as immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US10882844B2

  公开（公告）日：2021-01-05

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开内容一般涉及可用作免疫调节剂的化合物。本文提供了化合物、包含此类化合物的组合物及其使用方法。本公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，这些组合物可用于治疗各种疾病，包括癌症和传染性疾病。
• AMINOPYRAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0945439B1

  公开（公告）日：2003-03-19
• COMPOUNDS USEFUL AS IMMUNOMODULATORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3558970A1

  公开（公告）日：2019-10-30