2-[4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]acetamide
• 化学式: C₁₂H₁₄ClF₃N₄O
• 分子量: 322.71
• InChiKey: IOWDIVPZROBZGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Topoisomerase inhibitors
  申请人：Murphy A. Martin

  公开号：US20070004701A1

  公开（公告）日：2007-01-04

  The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.

  本发明提供了一些化合物，这些化合物有效地抑制拓扑异构酶（即拓扑异构酶I和/或拓扑异构酶II）。这些化合物被用于治疗细胞增殖性疾病。在某些情况下，这些化合物具有抗癌活性，例如对多药耐药癌症。
• US7683097B2
  申请人：——

  公开号：US7683097B2

  公开（公告）日：2010-03-23
• [EN] TOPOISOMERASE INHIBITORS<br/>[FR] INHIBITEURS DE TOPOISOMERASE
  申请人：PROPHARMACON INC

  公开号：WO2006022955A2

  公开（公告）日：2006-03-02

  The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.