2'-O-甲基鸟苷5'-三磷酸酯 | 61556-44-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 2'-O-甲基鸟苷5'-三磷酸酯
• 中文别名: 2'-甲氧基-鸟苷三磷酸
• 英文名称: 2'-O-methyl-GTP
• 英文别名: 2'-O-methylguanosine 5'-triphosphate；[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 61556-44-3
• 化学式: C₁₁H₁₈N₅O₁₄P₃
• 分子量: 537.21
• InChiKey: GMUJBFZJAFFHIW-KQYNXXCUSA-N

物化性质

• 密度：
  2.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  284
• 氢给体数：
  7
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  N'-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine 生成 2'-O-甲基鸟苷5'-三磷酸酯
  参考文献：
  名称：

  Novel solid phase synthesis of 2'-o-methylribonucleoside 5'-triphosphates and their α-thio analogues

  摘要：

  Simple, versatile and convenient syntheses of 2'-0-methyl-ribonucleoside 5'-triphosphates have been accomplished on controlled pore glass (CPG) in good yield (>60%) using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl phosphorochloridite). Moderate yields were obtained for the corresponding alpha-thiotri-phosphates.

  DOI：

  10.1016/s0040-4039(00)92072-0

文献信息

• Aptamer-toxin molecules and methods for using same
  申请人：——

  公开号：US20040249130A1

  公开（公告）日：2004-12-09

  Materials and methods are provided to prepare therapeutic conjugates for the treatment of proliferative diseases. The therapeutic conjugates of the invention comprise a targeting moiety conjugated to a therapeutic moiety. The therapeutic moiety of the conjugates of the present invention have a cytotoxic effect and are useful in the treatment of proliferative diseases.

  提供了用于治疗增生性疾病的治疗结合物的材料和方法。本发明的治疗结合物包括与治疗物质结合的靶向基团。本发明的结合物的治疗物质具有细胞毒作用，并可用于治疗增生性疾病。
• Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
  申请人：Diener John L.

  公开号：US20090105172A1

  公开（公告）日：2009-04-23

  The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.

  本发明提供了稳定的、高亲和力的核酸配体，用于与PSMA结合。本文描述了使用2'-O-甲基取代核酸的SELEX™方法和细胞表面SELEX™方法，鉴定和制备新的、稳定的、高亲和力的PSMA配体的方法。还包括使用所述核酸配体治疗和诊断PSMA表达疾病的方法和组合物。
• Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
  申请人：Diener L. John

  公开号：US20070041901A1

  公开（公告）日：2007-02-22

  The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.

  本发明提供了稳定的、高亲和力的核酸配体与PSMA结合。本文介绍了使用2'-O-甲基取代核酸的SELEX™方法以及细胞表面SELEX™方法鉴定和制备新型、稳定、高亲和力的PSMA配体的方法。还包括使用所述核酸配体进行治疗和诊断PSMA表达性疾病的方法和组合物。
• Nucleotide triphosphates and their incorporation into oligonucleotides
  申请人：——

  公开号：US20030004122A1

  公开（公告）日：2003-01-02

  The present invention relates to novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes or DNAzymes). Also, provided are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.

  本发明涉及新颖的核苷酸三磷酸盐，合成方法和将这些核苷酸三磷酸盐合成到寡核苷酸中的过程，以及新颖的核酸催化剂（例如核糖酶或DNA酶）的分离。此外，提供了使用新型酶促核酸分子抑制HER2 / neu / ErbB2基因表达的方法，并将其应用于人类治疗。
• Ribozymes directed against flt-1
  申请人：RIBOZYME PHARMACEUTICALS, INC.

  公开号：EP1321521A1

  公开（公告）日：2003-06-25

  Nucleic acid catalysts which modulate the expression of flt-1 gene; methods of delivery, screening, identification, synthesis, deprotection, purification of nucleic acid catalysts and process for identification of nucleic acid molecules is described.

  描述了调节 flt-1 基因表达的核酸催化剂；核酸催化剂的递送、筛选、鉴定、合成、脱保护、纯化方法以及核酸分子的鉴定过程。