2,4-二氧代-3-哌啶羧酸 | 220947-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2,4-二氧代-3-哌啶羧酸
• 英文名称: 2,4-Dioxopiperidine-3-carboxylic acid
• CAS: 220947-80-8
• 化学式: C₆H₇NO₄
• 分子量: 157.12
• InChiKey: MYLMBOMRQSIPHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Piperidone derivatives and medical uses thereof
  申请人：Heinrich-Pette-Institut

  公开号：EP2036556A1

  公开（公告）日：2009-03-18

  The present invention relates to compositions comprising 4-Oxo-piperidine-carboxylates and derivatives thereof, for example derivatives substituted with phenyl, nitrophenyl or benzyl groups. It also teaches the medical use of these and related compounds for treatment of retroviral diseases, in particular, HIV and HTLV, proliferative diseases, in particular CML and Trypanosomiasis.

  本发明涉及包含4-氧代哌啶羧酸酯及其衍生物的组合物，例如用苯基、硝基苯基或苄基取代的衍生物。它还教导了这些相关化合物的医药用途，用于治疗逆转录病毒性疾病，特别是HIV和HTLV，增殖性疾病，特别是慢性髓细胞白血病和锥虫病。
• [EN] PIPERIDONE DERIVATIVES AND MEDICAL USES THEREOF<br/>[FR] DÉRIVÉS DE PIPÉRIDONE ET LEURS UTILISATIONS MÉDICALES
  申请人：PETTE HEINRICH INST

  公开号：WO2009033689A1

  公开（公告）日：2009-03-19

  The present invention relates to compositions comprising 4- Oxo-piperidine-carboxylates and derivatives thereof, for example derivatives substituted with phenyl, nitrophenyl or benzyl groups. It also teaches the medical use of these and related compounds for treatment of retroviral diseases, in particular, HIV and HTLV, proliferative diseases, in particular CML and Trypanosomiasis.