N-[3-(2-oxopyrrolidin-1-yl)propyl]-6-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[3-(2-oxopyrrolidin-1-yl)propyl]-6-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]pyridine-3-carboxamide
• 化学式: C₂₆H₃₅N₇O₃
• 分子量: 493.6
• InChiKey: ZMGDOLLGIWHXJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NOVEL 2,5-PYRIDINEDICARBOXYLIC ACID DERIVATIVES<br/>[FR] NOUVEAUX DERIVES D'ACIDE 2,5-PYRIDINECARBOXYLIQUE
  申请人：DONG WHA PARM IND CO LTD

  公开号：WO1999058526A1

  公开（公告）日：1999-11-18

  The present invention relates to novel 2,5-pyridinedicarboxylic acid derivatives and more particularly, to novel 2,5-pyridinedicarboxylic acid derivatives of formula (1) and its pharmaceutically acceptable salts as anti retroviral agents, having inhibitory activities against the proliferation of retrovirus such as hepatitis B virus and human immunodeficiency virus, including its preparing method, wherein, R1, R2, R3 and n are the same as defined in the detailed description of the invention, respectively.