benzyl-(4-piperazin-1-yl-pyrimidin-2-yl)-amine | 426832-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: benzyl-(4-piperazin-1-yl-pyrimidin-2-yl)-amine
• 英文别名: N-benzyl-4-piperazin-1-ylpyrimidin-2-amine
• CAS: 426832-31-7
• 化学式: C₁₅H₁₉N₅
• 分子量: 269.349
• InChiKey: SGUBXKWIXLLZPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel compounds and their use
  申请人：——

  公开号：US20020147200A1

  公开（公告）日：2002-10-10

  A compound of the general formula (I): 1 wherein R 1 , R 2 , X, Y and Z are as described in the specification.

  通式（I）的化合物：其中R1、R2、X、Y和Z如规范中所述。
• [EN] DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR<br/>[FR] MODULATEURS DE DIAMINO-PYRIDINE, PYRIMIDINE ET PYRIDAZINE DU RÉCEPTEUR DE L'HISTAMINE H4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009152325A1

  公开（公告）日：2009-12-17

  Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

  二氨基吡啶、嘧啶和吡啉类化合物可用作H4受体调节剂，用于药物组合物和治疗H4受体活性介导的疾病状态、疾病和症状的方法，如过敏、哮喘、自身免疫疾病和瘙痒症。
• 5-HT receptor ligands and uses thereof
  申请人：——

  公开号：US20030105106A1

  公开（公告）日：2003-06-05

  Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT 2 receptors in animals are described herein. 1

  本文描述了作为5-HT受体配体的化合物（IA）及其在治疗与动物5-HT2受体激活相关的疾病中的用途。
• Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor
  申请人：Cai Hui

  公开号：US20110092474A1

  公开（公告）日：2011-04-21

  Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H 4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

  Diamino-pyridine，嘧啶和吡啶嗪化合物可用作H4受体调节剂，以及用于治疗由H4受体活性介导的疾病状态，紊乱和条件的制药组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
• Diamino-Pyridine, Pyrimidine, and Pyrazine Modulators of the Histamine H4 Receptor
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20140357614A1

  公开（公告）日：2014-12-04

  Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H 4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

  Diamino-pyridine、嘧啶和吡啶嗪化合物可用作H4受体调节剂，并用于制备药物组合物和治疗由H4受体活性介导的疾病状态、障碍和病况，例如过敏、哮喘、自身免疫疾病和瘙痒症的方法。