2-(3-氮杂双环[3.1.0]己-3-基)乙醇 | 743438-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2-(3-氮杂双环[3.1.0]己-3-基)乙醇
• 英文名称: 2-(3-Aza-bicyclo[3.1.0]hex-3-yl)-ethanol
• 英文别名: 2-(3-Azabicyclo[3.1.0]hexan-3-yl)ethan-1-ol；2-(3-azabicyclo[3.1.0]hexan-3-yl)ethanol
• CAS: 743438-31-5
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: ZTYGFHUOXIWCQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+)-4-((2S,3R)-6-(benzyloxy)-3-{3-[(triisopropylsilyl) oxy] phenyl}-2,3-dihydro-1,4-benzoxathiin-2-yl)phenol 、 2-(3-氮杂双环[3.1.0]己-3-基)乙醇 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成 3-(2-{4-[(2S,3R)-6-Benzyloxy-3-(4-triisopropylsilanyloxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-2-yl]-phenoxy}-ethyl)-3-aza-bicyclo[3.1.0]hexane
  参考文献：
  名称：

  Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

  摘要：

  A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects or, biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.074
• 作为产物：
  描述：

  3-氧杂二环[3.1.0]己烷-2,4-二酮 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-(3-氮杂双环[3.1.0]己-3-基)乙醇
  参考文献：
  名称：

  Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

  摘要：

  A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects or, biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.074

文献信息

• 5-Substituted indole-2-carboxamide derivatives
  申请人：Nettekoven Matthias

  公开号：US20070123525A1

  公开（公告）日：2007-05-31

  The present invention relates to compounds of formula I wherein R 1 to R 4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及公式I中的化合物，其中R1至R4和G如描述和索赔中定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• [EN] SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF<br/>[FR] MODULATEURS SÉLECTIFS DE LA KINASE ATAXIE TÉLANGIECTASIE MUTÉE (ATM) ET LEURS UTILISATIONS
  申请人：SUZHOU ZANRONG PHARMA LTD

  公开号：WO2022194138A1

  公开（公告）日：2022-09-22

  The specification relates to imidazo [4,5-c] cinnolin-2-one compounds and pharmaceutically acceptable salts thereof, which selectively modulate ataxia telangiectasia mutated ("ATM") kinase. The specification also relates to pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and to the use of the compounds and salts thereof in the treatment of ATM-associated diseases or conditions, including cancers.

  该规范涉及咪唑[4,5-c]茚并[2H]喹唑-2-酮化合物及其药学上可接受的盐，这些化合物可以选择性地调节共济失调毛细血管扩张性变异蛋白激酶（“ATM”）。该规范还涉及制药组合物，其包含一个或多个该化合物及其盐作为活性成分，以及在治疗ATM相关疾病或病症，包括癌症中使用该化合物及其盐的用途。
• Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers
  作者：Timothy A. Blizzard、Frank DiNinno、Jerry D. Morgan、Helen Y. Chen、Jane Y. Wu、Seongkon Kim、Wanda Chan、Elizabeth T. Birzin、Yi Tien Yang、Lee-Yuh Pai、Paula M.D. Fitzgerald、Nandini Sharma、Ying Li、Zhoupeng Zhang、Edward C. Hayes、Carolyn A. DaSilva、Wei Tang、Susan P. Rohrer、James M. Schaeffer、Milton L. Hammond

  DOI：10.1016/j.bmcl.2004.10.036

  日期：2005.1

  A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
• US7388095B2
  申请人：——

  公开号：US7388095B2

  公开（公告）日：2008-06-17