N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}benzamide hydrochloride | 783356-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}benzamide hydrochloride
• 英文别名: abexinostat hydrochloride；3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide;hydrochloride
• CAS: 783356-67-2
• 化学式: C₂₁H₂₃N₃O₅*ClH
• 分子量: 433.892
• InChiKey: DCLVURDKBXJXFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-[(二甲基氨基)甲基]-n-[2-[4-[(羟基氨基)羰基]苯氧基]乙基]-2-苯并呋喃羧酰胺 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 生成 N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}benzamide hydrochloride
  参考文献：
  名称：

  [EN] SOLID STATE FORMS OF ABEXINOSTAT AND PROCESS FOR PREPARATION THEREOF
  [FR] FORMES À L'ÉTAT SOLIDE D'ABEXINOSTAT ET LEUR PROCÉDÉ DE PRÉPARATION

  摘要：

  Solid state forms of Abexinostat salts and of Abexinostat tosylate : p-toluenesulfonic acid monohydrate complex, processes for preparation thereof, pharmaceutical compositions and uses thereof are disclosed.

  公开号：

  WO2022261401A1

文献信息

• [EN] HYDROXAMATES AS THERAPEUTIC AGENTS<br/>[FR] NOUVEAUX HYDROXAMATES ET LEUR UTILISATION COMME AGENTS THERAPEUTIQUES
  申请人：AXYS PHARM INC

  公开号：WO2004092115A3

  公开（公告）日：2005-02-17
• ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE
  申请人：Kloos Ioana

  公开号：US20130064880A1

  公开（公告）日：2013-03-14

  N-hydroxy-4-2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterised in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.
• ASSOCIATION BETWEEN N-HYDROXY-4-BENZAMIDE AND FOLFOX
  申请人：LES LABORATOIRES SERVIER

  公开号：US20150038513A1

  公开（公告）日：2015-02-05

  Association between N-hydroxy-4-2-[3-(N,N-dimethylaminomethyl)benzofuran-2-yl-carbonylamino]ethoxy}benzamide of formula (I): an addition salt thereof with a pharmaceutically acceptable acid or base, and FOLFOX. Medicaments.
• US8883199B2
  申请人：——

  公开号：US8883199B2

  公开（公告）日：2014-11-11
• [EN] SOLID STATE FORMS OF ABEXINOSTAT AND PROCESS FOR PREPARATION THEREOF<br/>[FR] FORMES À L'ÉTAT SOLIDE D'ABEXINOSTAT ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：[en]TEVA PHARMACEUTICALS INTERNATIONAL GMBH

  公开号：WO2022261401A1

  公开（公告）日：2022-12-15

  Solid state forms of Abexinostat salts and of Abexinostat tosylate : p-toluenesulfonic acid monohydrate complex, processes for preparation thereof, pharmaceutical compositions and uses thereof are disclosed.