(4-tert-Butylphenyl)diphenylmethanol | 6922-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (4-tert-Butylphenyl)diphenylmethanol
• 英文别名: -diphenyl-carbinol；4-tert.-Butyl-triphenylmethanol；Hydroxy-diphenyl-(4-tert.-butyl-phenyl)-methan；(4-Tert-butylphenyl)-diphenylmethanol
• CAS: 6922-88-9
• 化学式: C₂₃H₂₄O
• 分子量: 316.443
• InChiKey: ZKTVBNTUHPUHJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-tert-Butylphenyl)diphenylmethanol 在 乙酰氯 作用下， 以 甲苯 为溶剂， 生成 (4-tert-Butylphenyl)chlordiphenylmethan
  参考文献：
  名称：

  Sterically hindered free radicals. 14. Substituent-dependent stabilization of para-substituted triphenylmethyl radicals

  摘要：

  DOI：

  10.1021/ja00273a034
• 作为产物：
  描述：

  二氯二苯甲烷 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 生成 (4-tert-Butylphenyl)diphenylmethanol
  参考文献：
  名称：

  Zarkadis, Antonios K.; Neumann, Wilhelm P.; Uzick, Wolfram, Chemische Berichte, 1985, vol. 118, # 3, p. 1183 - 1192

  摘要：

  DOI：

文献信息

• A highly efficient nucleophilic substitution reaction between R₂P(O)H and triarylmethanols to synthesize phosphorus-substituted triarylmethanes
  作者：Long Chen、Xin-Yue Fang、Yun-Xiang Zou

  DOI：10.1039/c7ob02970e

  日期：——

  A highly efficient and general nucleophilic substitution reaction between dialkyl H-phosphonates or diarylphosphine oxides and triarylmethanols catalyzed by HOTf (trifluoromethanesulfonic acid) has been developed. It provides an atom-economical protocol for the synthesis of various symmetrical and unsymmetrical phosphorus-substituted triarylmethanes that constitute an emerging family of potent anticancer

  已经开发了由HOTf（三氟甲磺酸）催化的H-膦酸二烷基酯或二芳基膦氧化物与三芳基甲醇之间的高效且通用的亲核取代反应。它为合成各种对称和不对称的磷取代的三芳基甲烷提供了一种原子经济的方法，这些化合物构成了新兴的强效抗癌剂家族，具有丰富的多样性，产率为40％至96％。该协议的综合适用性已通过克量级的制备证明。
• Understanding Actinides through the Role of 5<i>f</i> Electrons
  作者：T. Gouder、F. Wastin、J. Rebizant、G.H. Lander

  DOI：10.1557/mrs2001.178

  日期：2001.9

  Studies of the actinide elements and compounds were (and are) motivated by the need to characterize their structural and thermodynamic properties for the development of nuclear fuels and the treatment of waste, whether it be for long-term storage or ideas involving transmutation in high-powered accelerators. For the most part, tables giving these data exist, although the data for transuranium compounds are rather sparse. A much more difficult task is to understand the data and develop theories that have predictive power in this part of the periodic table. In doing this, however, we are confronted with the extremely complicated electronic structure of the 5f shell and the great paucity of high-quality data on materials containing transuranium isotopes.

  对锕系元素和化合物的研究（过去和现在）是为了表征它们的结构和热力学性质，以便开发核燃料和处理废物，无论是用于长期存储还是涉及在高能加速器中进行转变的想法。在很大程度上，存在着提供这些数据的表格，尽管超铀化合物的数据相当稀缺。一个更加困难的任务是理解这些数据，并发展在周期表这一部分具有预测能力的理论。然而，在这个过程中，我们面临着5f壳层的极其复杂的电子结构以及含有超铀同位素材料的高质量数据的严重匮乏。
• Structure−Activity Relationship and Multidrug Resistance Study of New <i>S</i>-trityl-<scp>l</scp>-Cysteine Derivatives As Inhibitors of Eg5
  作者：Hung Yi Kristal Kaan、Johanna Weiss、Dominik Menger、Venkatasubramanian Ulaganathan、Katarzyna Tkocz、Christian Laggner、Florence Popowycz、Benoît Joseph、Frank Kozielski

  DOI：10.1021/jm100991m

  日期：2011.3.24

  The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse. However, toxicity and resistance are problems associated with these drugs. Thus, alternative approaches to inhibiting the mitotic spindle are being pursued. These include targeting Eg5, a human kinesin involved in the formation of the bipolar spindle. We previously identified S-trityl-L-cysteine (STLC) as a potent allosteric inhibitor of Eg5. Here, we report the synthesis of a new series of STLC-like compounds with in vitro inhibition in the low nanomolar range. We also performed a multidrug resistance study in cell lines overexpressing P-glycoprotein and showed that some of these inhibitors may have the potential to overcome susceptibility to this efflux pump. Finally, we performed molecular docking of the compounds and determined the structures of two Eg5-inhibitor complexes to explain the structure-activity relationship of these compounds.
• THE EFFECT OF HALOGEN ATOMS AND OF ALKYL GROUPS ON THE RATES OF DISSOCIATION OF PENTAARYLETHANES
  作者：W. E. BACHMANN、E. CARLSON、J. C. MORAN

  DOI：10.1021/jo01164a023

  日期：1948.11
• The ionization of organic halides in nitroalkanes
  作者：Alwyn G. Evans、J. A. G. Jones、G. O. Osborne

  DOI：10.1039/tf9545000016

  日期：——