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2-benzyl-2-azabicyclo[3.3.1]nonane-3,6-dione | 198290-34-5

中文名称
——
中文别名
——
英文名称
2-benzyl-2-azabicyclo[3.3.1]nonane-3,6-dione
英文别名
2-Benzyl-2-aza-bicyclo[3.3.1]nonane-3,6-dione
2-benzyl-2-azabicyclo[3.3.1]nonane-3,6-dione化学式
CAS
198290-34-5
化学式
C15H17NO2
mdl
——
分子量
243.305
InChiKey
SKQXROYENHPSCB-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.2
  • 重原子数:
    18
  • 可旋转键数:
    2
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.47
  • 拓扑面积:
    37.4
  • 氢给体数:
    0
  • 氢受体数:
    2

反应信息

  • 作为反应物:
    描述:
    2-benzyl-2-azabicyclo[3.3.1]nonane-3,6-dione 作用下, 以 溶剂黄146 为溶剂, 反应 2.0h, 以88%的产率得到2-benzyl-7,7-dibromo-2-aza-bicyclo[3.3.1]nonane-3,6-dione
    参考文献:
    名称:
    [EN] ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE
    [FR] DÉRIVÉS ARYL- ET HÉTÉROARYLCARBONYLES DE BENZOMORPHANES ET STRUCTURES LIÉES À CEUX-CI, MÉDICAMENTS CONTENANT DE TELS COMPOSÉS ET LEUR UTILISATION
    摘要:
    公开号:
    WO2009063061A3
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文献信息

  • Aryl-and Heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Himmelsbach Frank
    公开号:US20110190262A1
    公开(公告)日:2011-08-04
    The present invention relates to compounds defined by formula I wherein the groups R 1 to R 3 , X, m, n and o are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及公式I所定义的化合物,其中R1至R3、X、m、n和o的定义如权利要求书中所述,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇酶(HSD)1的抑制剂,因此适用于治疗和预防可以通过抑制该酶而受影响的疾病,如代谢性疾病,特别是2型糖尿病、肥胖症和血脂异常。
  • Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Himmelsbach Frank
    公开号:US08859580B2
    公开(公告)日:2014-10-14
    The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及公式I定义的化合物,其中R1至R3、X、m、n和o组的定义如权利要求书中所述,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇酶(HSD)1的抑制剂,因此适用于治疗和预防可以受到该酶抑制影响的疾病,例如代谢性疾病,特别是2型糖尿病、肥胖症和血脂异常。
  • Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Eckhardt Matthias
    公开号:US20110028445A1
    公开(公告)日:2011-02-03
    The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及由式(I)定义的化合物,其中A,B,X,m,n和o的基团如权利要求1中所定义,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇酶(HSD)1的抑制剂,因此适用于治疗和预防可以通过抑制该酶而受到影响的疾病,如代谢性疾病,特别是2型糖尿病,肥胖症和血脂异常。
  • ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE
    申请人:Boehringer Ingelheim International GmbH
    公开号:EP2220048A2
    公开(公告)日:2010-08-25
  • UREA DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE
    申请人:Boehringer Ingelheim International GmbH
    公开号:EP2245014A1
    公开(公告)日:2010-11-03
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