4-(3-fluoro-4-methoxybenzyl)piperidine hydrochloride salt | 1171578-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(3-fluoro-4-methoxybenzyl)piperidine hydrochloride salt
• 英文别名: 4-(3-Fluoro-4-methoxy-benzyl)-piperidine hydrochloride；4-[(3-fluoro-4-methoxyphenyl)methyl]piperidine;hydrochloride
• CAS: 1171578-73-6
• 化学式: C₁₃H₁₈FNO*(x)ClH
• 分子量: 259.75
• InChiKey: KVRUPCCEMZAYJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF TISSUE FIBROSIS
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：EP3083584B1

  公开（公告）日：2018-02-21
• NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US20160355501A1

  公开（公告）日：2016-12-08

  The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.
• US9902712B2
  申请人：——

  公开号：US9902712B2

  公开（公告）日：2018-02-27