| 623575-44-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• CAS: 623575-44-0；654065-32-4
• 化学式: C₂₂H₄₈OSiSn
• 分子量: 475.418
• InChiKey: IKKFBLYAJXIMEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.34
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  在 2-碘酰基苯甲酸 作用下， 以 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 15.17h， 生成
  参考文献：
  名称：

  Intramolecular cyclization strategies toward the synthesis of zoanthamine alkaloids

  摘要：

  Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.054
• 作为产物：
  描述：

  三正丁基氢锡 、 2-叔丁基二甲基硅氧基丁-3-炔 在 偶氮二异丁腈 作用下， 以 not given 为溶剂， 以64%的产率得到
  参考文献：
  名称：

  (-)-Incarvilline、(+)-Incarvine C 和 (-)-Incarvillateine 的全合成

  摘要：

  与天然对映体相对应的新单萜生物碱 (-)-incarvilline、(+)-incarvine C 和 (-)-incarvillateine 的首次全合成已经完成。这些天然产物的合成策略利用 6-epi-incarvilline 作为常见的前体，通过三组分偶联反应使用 (4S)-4-siloxy-2-cyclopenten-1-one 组装以构建适当的三取代的环戊酮，然后通过还原性 Heck 型反应闭环到顺式-全氢-2-吡啶骨架。此外，还研究了固态肉桂酸衍生物的拓扑化学控制 [2 + 2] 光二聚化，用于立体定向构建 1,2,3,4-四取代环丁烷环，作为获取 (-)-incarvillateine 的一种手段。

  DOI：

  10.1021/ja0401702

文献信息

• Synthesis and structure–activity relationship of kujigamberol B, a dinorlabdane diterpenoid isolated from an ancient Kuji amber
  作者：Sakura Kishibata、Kurumi Tanaka、Tatsuo Saito、Ken-ichi Kimura、Arata Yajima

  DOI：10.1093/bbb/zbad027

  日期：——

  The versatile methodology was developed for synthesizing kujigamberol B, a dinorlabdane diterpenoid isolated from the methanol extract of Kuji amber. A highly efficient intramolecular cyclization is followed by a Sonogashira-coupling reaction during the total synthesis. The synthesized compounds were evaluated for the growth-restoring activity against the mutant yeast (zds1Δ erg3Δ pdr1Δ pdr3Δ) and

  开发了用于合成 kujigamberol B 的多功能方法，kujigamberol B 是一种从 Kuji 琥珀的甲醇提取物中分离出来的二萘并萘烷二萜类化合物。在全合成过程中，高效的分子内环化之后是 Sonogashira 偶联反应。评估了合成化合物对突变酵母 (zds1Δ erg3Δ pdr1Δ pdr3Δ) 的生长恢复活性和 RBL-2H3 细胞的脱颗粒作用。我们发现在这两种活动中，伯醇和仲醇类似物与 kujigamberol B 一样活跃。
• OREXIN RECEPTOR AGONISTS
  申请人：[en]MERCK SHARP & DOHME LLC

  公开号：WO2024107615A1

  公开（公告）日：2024-05-23

  The present invention is directed to compounds of Formula I which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
• Total Synthesis of (−)-Incarvilline, (+)-Incarvine C, and (−)-Incarvillateine
  作者：Masaya Ichikawa、Masaki Takahashi、Sakae Aoyagi、Chihiro Kibayashi

  DOI：10.1021/ja0401702

  日期：2004.12.1

  The first total syntheses of new monoterpene alkaloids (-)-incarvilline, (+)-incarvine C, and (-)-incarvillateine, corresponding to the natural enantiomers, have been accomplished. The strategy for the synthesis of these natural products utilized 6-epi-incarvilline as a common precursor, which was assembled by a three-component coupling reaction using (4S)-4-siloxy-2-cyclopenten-1-one to construct

  与天然对映体相对应的新单萜生物碱 (-)-incarvilline、(+)-incarvine C 和 (-)-incarvillateine 的首次全合成已经完成。这些天然产物的合成策略利用 6-epi-incarvilline 作为常见的前体，通过三组分偶联反应使用 (4S)-4-siloxy-2-cyclopenten-1-one 组装以构建适当的三取代的环戊酮，然后通过还原性 Heck 型反应闭环到顺式-全氢-2-吡啶骨架。此外，还研究了固态肉桂酸衍生物的拓扑化学控制 [2 + 2] 光二聚化，用于立体定向构建 1,2,3,4-四取代环丁烷环，作为获取 (-)-incarvillateine 的一种手段。
• Intramolecular cyclization strategies toward the synthesis of zoanthamine alkaloids
  作者：Derek Fischer、Thong X. Nguyen、Lynnie Trzoss、Marianna Dakanali、Emmanuel A. Theodorakis

  DOI：10.1016/j.tetlet.2011.07.054

  日期：2011.9

  Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented. (C) 2011 Elsevier Ltd. All rights reserved.