2-vinylthiochroman-4-one | 1104378-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 2-vinylthiochroman-4-one
• 英文别名: 2-Ethenyl-2,3-dihydrothiochromen-4-one
• CAS: 1104378-41-7
• 化学式: C₁₁H₁₀OS
• 分子量: 190.266
• InChiKey: UJUZIYCNGKUFPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙烯基氯化镁 、 在 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以126 mg的产率得到2-vinylthiochroman-4-one
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones

  摘要：

  2-Alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones, and 2-alkenylquinol-4-ones were prepared with very good regioselectivity by Me3SiOTf-mediated conjugate addition of alkenylmagnesium bromides and alkenyllithium compounds to chromones thiochromones, and quinol-4-ones. A number of products exhibit a considerable antimicrobial activity. The best activity, with respect to the spectrum of antimicrobial activity, was observed for 2-vinylchroman-4-ones containing an unsubstituted vinyl group and a chloride group located at the chromanone moiety. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.043

文献信息

• Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones
  作者：Nicole Hoettecke、Sven Rotzoll、Uwe Albrecht、Michael Lalk、Christine Fischer、Peter Langer

  DOI：10.1016/j.bmc.2008.10.043

  日期：2008.12.15

  2-Alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones, and 2-alkenylquinol-4-ones were prepared with very good regioselectivity by Me3SiOTf-mediated conjugate addition of alkenylmagnesium bromides and alkenyllithium compounds to chromones thiochromones, and quinol-4-ones. A number of products exhibit a considerable antimicrobial activity. The best activity, with respect to the spectrum of antimicrobial activity, was observed for 2-vinylchroman-4-ones containing an unsubstituted vinyl group and a chloride group located at the chromanone moiety. (C) 2008 Elsevier Ltd. All rights reserved.