bis(diisopropylamino)vinyl phosphine | 89438-04-0

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: bis(diisopropylamino)vinyl phosphine
• 英文别名: Vinylphosphonous bis(diisopropylamide)；N-[[di(propan-2-yl)amino]-ethenylphosphanyl]-N-propan-2-ylpropan-2-amine
• CAS: 89438-04-0
• 化学式: C₁₄H₃₁N₂P
• 分子量: 258.387
• InChiKey: TUVOHKWYQUTNCM-UHFFFAOYSA-N

物化性质

• 熔点：
  26-27 °C
• 沸点：
  77-80 °C(Press: 0.3 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis(diisopropylamino)vinyl phosphine 在 钌 四氮唑 、 叔丁基过氧化氢 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 ((3aR,3bS,7aR,8aR)-2,2-Dimethyl-5-oxo-3a,5,7a,8a-tetrahydro-3bH-1,3,4,8-tetraoxa-5λ⁵-phospha-cyclopenta[a]inden-5-yl)-diisopropyl-amine
  参考文献：
  名称：

  An expeditious route to phosphorus heterocycles based on ring-closing metathesis

  摘要：

  A convenient route for the synthesis of phosphorus diolefinic templates starting from the bifunctional reagent bis(diisopropylamino)vinylphosphine is presented. Ring closing olefin metathesis on this type of diene substrate revealed that the newly developed 4,5-dihydro-imidazol-2-ylidene ruthenium benzylidene complex 4 is in all aspects superior to the previously developed Grubbs' catalyst 1. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01511-2
• 作为产物：
  描述：

  在 氢氧化钾 作用下， 以 四氢呋喃 为溶剂， 生成 bis(diisopropylamino)vinyl phosphine
  参考文献：
  名称：

  New Types of Stable Aldehydes: Formylphosphane and Formylphosphane Oxide

  摘要：

  The reactivity of the formyl group in alpha-phosphorus-substituted aldehydes 1 can be tuned by adjusting the coordination number of the phosphorus atom. When X is a lone pair, the formylphosphanes obtained are stable compounds, whereas when X=O a relatively unstable formylphosphane oxide is produced. R=iPr(2)N, cHex(2)N.

  DOI：

  10.1002/(sici)1521-3773(19990802)38:15<2201::aid-anie2201>3.0.co;2-e

文献信息

• [EN] CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES<br/>[FR] CONJUGAISON CHIMIOSÉLECTIVE D'UN THIOL AVEC DES ALCÈNE- OU ALCYNE-PHOSPHONAMIDATES
  申请人：FORSCHUNGSVERBUND BERLIN EV

  公开号：WO2018041985A1

  公开（公告）日：2018-03-08

  Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).

  揭示了新颖的结合物和其制备方法。一种制备烯烃或炔烃磷酰胺酯的方法包括以下步骤：(I)将式（III）的化合物与式（IV）的叠氮化合物反应，制备出式（V）的化合物，将式（V）的化合物与式（VI）的含硫醇分子反应，得到式（VII）的化合物。
• Synthesis of dinucleotides with 2′-C to phosphate connections by ring-closing metathesis
  作者：Philip Børsting、Mikkel S. Christensen、Signe I. Steffansen、Poul Nielsen

  DOI：10.1016/j.tet.2005.10.074

  日期：2006.2

  nucleosides with olefinic 2′-modifications were prepared; 2′-C-methylene, 2′-C-(propen-1-yl), 2′-C-allyl and 2′-O-allyl uridines, respectively. These were incorporated into dinucleotides with allyl phosphate or vinyl phosphonate linkages. Hence, six different dinucleotides were studied as substrates for RCM reactions, and from four of these, cyclic dinucleotides with connections between 2′-C and phosphorus

  制备了具有烯烃2'-修饰的四个不同的核苷。2′- C-亚甲基，2′ - C-（丙烯-1-基），2′- C-烯丙基和2′- O-烯丙基尿苷。将它们掺入具有烯丙基磷酸酯或乙烯基膦酸酯键的二核苷酸中。因此，研究了六种不同的二核苷酸作为RCM反应的底物，并从其中的四个中获得了2'-C和3-6个原子的磷之间有连接的环状二核苷酸。
• Synthesis of mono- and di-cationic phosphorus–zirconium species
  作者：Florence Boutonnet、Maria Zablocka、Alain Igau、Jean-Pierre Majoral、Bernard Raynaud、Joël Jaud

  DOI：10.1039/c39930001866

  日期：——

  Synthesis and characterisation of zirconium containing phosphonium salts are reported, including the X-ray molecular structure determination of [(Pri2)N}2P(Me)(CH2)2C(NBut)Zr(η-C5H5)2OSO2CF3]OSO2CF35a; lability of the zirconium–oxygen covalent bond in 5a allows the preparation of the phosphorus–zirconium dicationic species 6a[(Pri2)N}2P(Me)(CH2)2C(NBut)Zr(η-C5H5)][(OSO2CF3)]2.

  合成和含鏻盐锆的表征报告，其中包括[（PR的透视分子结构判定我2）N} 2 P（Me）的（CH 2）2 C（NBU吨基）Zr（η-C 5 H 5）2 OSO 2 CF 3 ] OSO 2 CF 3 5a；5a中锆-氧共价键的不稳定性使得可以制备磷-锆双效键合物种6a [（Pr i 2）N} 2 P（Me）（CH 2）2 C（NBU吨基）Zr（η-C 5 H ^ 5）] [（OSO 2 CF 3）] 2。
• Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
  申请人：FORSCHUNGSVERBUND BERLIN E.V.

  公开号：US11161873B2

  公开（公告）日：2021-11-02

  Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).

  本发明公开了新型共轭物及其制备工艺。制备烯烃或炔膦酸盐的工艺包括以下步骤：(I) 将式 (III) 的化合物与式 (IV) 的叠氮化物反应，制备式 (V) 的化合物；将式 (V) 的化合物与式 (VI) 的含硫醇分子反应，得到式 (VII) 的化合物。
• Bis(dialkylamino)phosphines
  作者：R. Bruce King、P. M. Sundaram

  DOI：10.1021/jo00184a022

  日期：1984.5