(5-methyl-thieno[2,3-d]pyrimidin-4-yl)-(2-piperidin-1-yl-phenyl)-amine | 917907-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (5-methyl-thieno[2,3-d]pyrimidin-4-yl)-(2-piperidin-1-yl-phenyl)-amine
• 英文别名: 5-Methyl-N-[2-(piperidin-1-yl)phenyl]thieno[2,3-d]pyrimidin-4-amine；5-methyl-N-(2-piperidin-1-ylphenyl)thieno[2,3-d]pyrimidin-4-amine
• CAS: 917907-36-9
• 化学式: C₁₈H₂₀N₄S
• 分子量: 324.45
• InChiKey: QMSFSTKZKNDWQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：Taylor Steven

  公开号：US20100143341A1

  公开（公告）日：2010-06-10

  The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

  本发明涉及通式（I）的新型药物组合物，其包括噻唑嘧啶化合物。此外，本发明涉及使用本发明的噻唑嘧啶化合物生产药物组合物，用于预防和/或治疗可以通过抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b）及/或其变体的激酶活性而受到影响的疾病。
• [EN] THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS<br/>[FR] THIÉNOPYRIMIDINES POUR COMPOSITIONS PHARMACEUTIQUES
  申请人：DEVELOGEN AG

  公开号：WO2006136402A1

  公开（公告）日：2006-12-28

  [EN] The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
  [FR] L'invention concerne de nouvelles compositions pharmaceutiques de formule (I) renfermant des composés thiénopyrimidines. L'invention porte également sur l'utilisation des composés thiénopyrimidines précités dans la production de compositions pharmaceutiques destinées à la prophylaxie et/ou au traitement de maladies qui peuvent être influencées par l'inhibition de l'activité kinase de Mnk1 et/ou Mnk2 (Mnk2a ou Mnk2b) et/ou de variants de ces derniers.
• [EN] NOVEL USE OF THIENOPYRIMIDINES<br/>[FR] NOUVELLE UTILISATION DE THIÉNOPYRIMIDINES
  申请人：DEVELOGEN AG

  公开号：WO2007059905A2

  公开（公告）日：2007-05-31

  (EN) The present invention relates to the use of thienopyrimidine compounds for the production of pharmaceutical compositions for the treatment of inflammatory diseases.(FR) La présente invention concerne l’utilisation de composés de thiénopyrimidine pour la production de compositions pharmaceutiques pour le traitement de maladies inflammatoires.
• [EN] THIENOPYRIMIDINES TREATING INFLAMMATORY DISEASES<br/>[FR] NOUVELLE UTILISATION DE THIÉNOPYRIMIDINES
  申请人：DEVELOGEN AG

  公开号：WO2007059905A9

  公开（公告）日：2007-11-01

  [EN] The present invention relates to the use of thienopyrimidine compounds for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
  [FR] La présente invention concerne l'utilisation de composés de thiénopyrimidine pour la production de compositions pharmaceutiques pour le traitement de maladies inflammatoires.