2-(仲-丁基)-4,5-二氢噻唑 | 56367-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 2-(仲-丁基)-4,5-二氢噻唑
• 英文名称: 2-sec-Butyl-Δ²-thiazoline
• 英文别名: 2-(1-methylpropyl)-2-thiazoline；2-sec-butyl-4,5-dihydrothiazole；2-sec-butyl-4,5-dihydro-thiazole；2-sec-butyl-2-thiazoline；2-sec-Butyl-4,5-dihydrothiazol；2-sec.Butyl-thiazol；2-(sec-Butyl)-4,5-dihydrothiazole；2-butan-2-yl-4,5-dihydro-1,3-thiazole
• CAS: 56367-27-2
• 化学式: C₇H₁₃NS
• 分子量: 143.253
• InChiKey: SAWWKXMIPYUIBW-UHFFFAOYSA-N

物化性质

• 沸点：
  193.0±9.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  2-8℃，干燥且密封保存。

反应信息

• 作为产物：
  描述：

  3-(2-aminoethanethio)-4-methylhex-2-enenitrile 以71%的产率得到2-(仲-丁基)-4,5-二氢噻唑
  参考文献：
  名称：

  Allenes-41

  摘要：

  DOI：

  10.1016/s0040-4020(01)88457-x

文献信息

• SUBSTITUTED 2-HETEROCYCLYLIMIDAZOLYLCARBOXAMIDES AS PESTICIDES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20190166837A1

  公开（公告）日：2019-06-06

  The present invention relates to compounds of the general formula (I) in which Q, V, T, W, Y, X and A have the meanings given in the description—and to a process for preparation thereof and to the use thereof for controlling animal pests.

  本发明涉及一般式（I）中的化合物，其中Q、V、T、W、Y、X和A具有描述中给出的含义，以及用于制备这些化合物的方法和用于控制动物害虫的用途。
• Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
  作者：Yibing Wang、Liqin Cao、Chia-Ying Lee、Tomohiko Matsuo、Kejia Wu、Greg Asher、Lijun Tang、Tsuyoshi Saitoh、Jamie Russell、Daniela Klewe-Nebenius、Li Wang、Shingo Soya、Emi Hasegawa、Yoan Chérasse、Jiamin Zhou、Yuwenbin Li、Tao Wang、Xiaowei Zhan、Chika Miyoshi、Yoko Irukayama、Jie Cao、Julian P. Meeks、Laurent Gautron、Zhiqiang Wang、Katsuyasu Sakurai、Hiromasa Funato、Takeshi Sakurai、Masashi Yanagisawa、Hiroshi Nagase、Reiko Kobayakawa、Ko Kobayakawa、Bruce Beutler、Qinghua Liu

  DOI：10.1038/s41467-018-04324-3

  日期：——

  Innate behaviors are genetically encoded, but their underlying molecular mechanisms remain largely unknown. Predator odor 2,4,5-trimethyl-3-thiazoline (TMT) and its potent analog 2-methyl-2-thiazoline (2MT) are believed to activate specific odorant receptors to elicit innate fear/defensive behaviors in naive mice. Here, we conduct a large-scale recessive genetics screen of ethylnitrosourea (ENU)-mutagenized mice. We find that loss of Trpa1, a pungency/irritancy receptor, diminishes TMT/2MT and snake skin-evoked innate fear/defensive responses. Accordingly, Trpa1 ^−/− mice fail to effectively activate known fear/stress brain centers upon 2MT exposure, despite their apparent ability to smell and learn to fear 2MT. Moreover, Trpa1 acts as a chemosensor for 2MT/TMT and Trpa1-expressing trigeminal ganglion neurons contribute critically to 2MT-evoked freezing. Our results indicate that Trpa1-mediated nociception plays a crucial role in predator odor-evoked innate fear/defensive behaviors. The work establishes the first forward genetics screen to uncover the molecular mechanism of innate fear, a basic emotion and evolutionarily conserved survival mechanism.

  先天行为是基因编码的，但它们的基本分子机制仍然大多数未知。掠食者气味2,4,5-三甲基-3-硫唑烷（TMT）及其有效类似物2-甲基-2-硫唑烷（2MT）被认为通过激活特定的气味受体，在天真的老鼠中引起先天恐惧/防御行为。在这里，我们对乙基亚硝胺（ENU）诱变的小鼠进行了大规模的隐性遗传学筛选。我们发现，失去辣味/刺激性受体Trpa1会减弱TMT/2MT和蛇皮引起的先天恐惧/防御反应。因此，Trpa1^−/−小鼠在2MT暴露时无法有效激活已知的恐惧/压力大脑中心，尽管它们明显能够嗅到并学会恐惧2MT。此外，Trpa1作为2MT/TMT的化学感受器，Trpa1表达的三叉神经节神经元对2MT诱导的冻结反应起着至关重要的作用。我们的结果表明，Trpa1介导的痛觉感受在掠食者气味引起的先天恐惧/防御行为中起着重要作用。该研究建立了第一个前向遗传学筛选，揭示了先天恐惧的分子机制，这是一种基本情感和进化保守的生存机制。

• Polyamide-polyether block copolymer
  申请人：Pavlin S. Mark

  公开号：US20060052576A1

  公开（公告）日：2006-03-09

  Copolymers having linked internal polyether blocks and internal polyamide blocks have advantageous physical properties and solvent-gelling abilities. The copolymer may be prepared from a reaction mixture that contains 1,4-cyclohexane dicarboxylic acid (CHDA) and poly(alkyleneoxy) diamine (PAODA). Optionally, the reaction mixture contains no monofunctional compound reactive with either amine or carboxylic acid groups, however some of this monofunctional compound may be present. Dimer diamine and/or dimer acid may be present in the reaction mixture. A copolymer may also be prepared from a reaction mixture containing dimer acid and at least two diamine compound(s) including PAODA and short-chain aliphatic diamine having 2-6 carbons (SDA), wherein: a) the reaction mixture comprises x grams of PAODA and y grams of SDA, and x/(x+y) is 0.8-0.98; b) the reaction mixture weighs z grams, and x/z is at least 0.25; and c) the reaction mixture contains either no co-diacid, or comprises a small amount of co-diacid, wherein, if the reaction mixture comprises a small amount of co-diacid, then acid equivalents from co-diacid contribute less than 25% of the total acid equivalents present in the reaction mixture.

  具有连接的内部聚醚块和内部聚酰胺块的共聚物具有有利的物理性能和溶剂凝胶能力。该共聚物可以从包含1,4-环己烷二甲酸（CHDA）和聚（烷氧基）二胺（PAODA）的反应混合物中制备。可选地，反应混合物不含与胺或羧酸基反应的单官能化合物，但其中一些单官能化合物可能存在。二聚胺和/或二聚酸可以存在于反应混合物中。还可以从包含二聚酸和至少两种二胺化合物（包括PAODA和具有2-6个碳的短链脂肪族二胺（SDA））的反应混合物中制备共聚物，其中：a）反应混合物包含x克PAODA和y克SDA，且x/（x+y）为0.8-0.98；b）反应混合物重z克，且x/z至少为0.25；c）反应混合物不含共二酸，或包含少量共二酸，其中，如果反应混合物包含少量共二酸，则共二酸的酸当量贡献的总酸当量不超过反应混合物中总酸当量的25％。
• POLYAMIDE-POLYETHER BLOCK COPOLYMER
  申请人：Pavlin S. Mark

  公开号：US20070244294A1

  公开（公告）日：2007-10-18

  Copolymers having linked internal polyether blocks and internal polyamide blocks have advantageous physical properties and solvent-gelling abilities. The copolymer may be prepared from a reaction mixture that contains 1,4-cyclohexane dicarboxylic acid (CHDA) and poly(alkyleneoxy) diamine (PAODA). Optionally, the reaction mixture contains no monofunctional compound reactive with either amine or carboxylic acid groups, however some of this monofunctional compound may be present. Dimer diamine and/or dimer acid may be present in the reaction mixture. A copolymer may also be prepared from a reaction mixture containing dimer acid and at least two diamine compound(s) including PAODA and short-chain aliphatic diamine having 2-6 carbons (SDA), wherein: a) the reaction mixture comprises x grams of PAODA and y grams of SDA, and x/(x+y) is 0.8-0.98; b) the reaction mixture weighs z grams, and x/z is at least 0.25; and c) the reaction mixture contains either no co-diacid, or comprises a small amount of co-diacid, wherein, if the reaction mixture comprises a small amount of co-diacid, then acid equivalents from co-diacid contribute less than 25% of the total acid equivalents present in the reaction mixture.

  具有连接的内部聚醚块和内部聚酰胺块的共聚物具有优越的物理性能和溶剂凝胶能力。该共聚物可以从含有1,4-环己烷二羧酸（CHDA）和聚（烷氧基）二胺（PAODA）的反应混合物中制备。可选地，反应混合物不含与胺基或羧酸基反应的单官能化合物，但其中一些单官能化合物可能存在。二聚胺和/或二聚酸可以存在于反应混合物中。共聚物也可以从含有二聚酸和至少两种二胺化合物（包括PAODA和具有2-6个碳的短链脂肪族二胺（SDA））的反应混合物中制备，其中：a）反应混合物包含x克PAODA和y克SDA，且x/（x+y）为0.8-0.98；b）反应混合物重z克，且x/z至少为0.25；c）反应混合物不含共二酸，或包含少量共二酸，其中，如果反应混合物包含少量共二酸，则共二酸的酸当量贡献的总酸当量不超过反应混合物中总酸当量的25％。
• Polyamide-Polyether Block Copolymer
  申请人：Pavlin Mark S.

  公开号：US20090076175A1

  公开（公告）日：2009-03-19

  Copolymers having linked internal polyether blocks and internal polyamide blocks have advantageous physical properties and solvent-gelling abilities. The copolymer may be prepared from a reaction mixture that contains 1,4-cyclohexane dicarboxylic acid (CHDA) and poly(alkyleneoxy) diamine (PAODA). Optionally, the reaction mixture contains no monofunctional compound reactive with either amine or carboxylic acid groups, however some of this monofunctional compound may be present. Dimer diamine and/or dimer acid may be present in the reaction mixture. A copolymer may also be prepared from a reaction mixture containing dimer acid and at least two diamine compound(s) including PAODA and short-chain aliphatic diamine having 2-6 carbons (SDA), wherein: a) the reaction mixture comprises x grams of PAODA and y grams of SDA, and x/(x+y) is 0.8-0.98; b) the reaction mixture weighs z grams, and x/z is at least 0.25; and c) the reaction mixture contains either no co-diacid, or comprises a small amount of co-diacid, wherein, if the reaction mixture comprises a small amount of co-diacid, then acid equivalents from co-diacid contribute less than 25% of the total acid equivalents present in the reaction mixture.

  具有连接内部聚醚块和内部聚酰胺块的共聚物具有优越的物理性能和溶剂凝胶能力。该共聚物可以从包含1,4-环己烷二甲酸（CHDA）和聚（烷氧基）二胺（PAODA）的反应混合物中制备。可选地，反应混合物不含对胺基或羧酸基反应的单官能化合物，但该单官能化合物的一些可能存在。二聚胺和/或二聚酸可以存在于反应混合物中。共聚物也可以从包含二聚酸和至少两种二胺化合物（包括PAODA和具有2-6个碳的短链脂肪族二胺（SDA））的反应混合物中制备，其中：a）反应混合物包含x克PAODA和y克SDA，且x/（x+y）为0.8-0.98；b）反应混合物重z克，且x/z至少为0.25；c）反应混合物不含共二酸，或包含少量共二酸，其中，如果反应混合物包含少量共二酸，则共二酸的酸当量对反应混合物中存在的总酸当量贡献不超过25％。