(4R,5R,E)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethyloct-6-enal | 1323142-15-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (4R,5R,E)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethyloct-6-enal
• 英文别名: (E,4R,5R)-5-[tert-butyl(dimethyl)silyl]oxy-2,4,6-trimethyloct-6-enal
• CAS: 1323142-15-9
• 化学式: C₁₇H₃₄O₂Si
• 分子量: 298.541
• InChiKey: SHWSPXCERTXRMT-ZBYIVTBVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R,5R,E)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethyloct-6-enal 在 哌啶 、 indium(III) chloride 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 、
  参考文献：
  名称：

  Accessing the Structural Diversity of Pyridone Alkaloids: Concise Total Synthesis of Rac-Citridone A

  摘要：

  A unique route to the structural diversity of pyridone alkaloids is described based on the concept of a common synthetic strategy. Three different core structure analogues corresponding to akanthomycin, septoriamycin A, and cltridone A have been prepared by using a highly selective and novel carbocyclization reaction.

  DOI：

  10.1021/ol2017802
• 作为产物：
  描述：

  (2R,3R,4E)-3-(tert-Butyldimethylsiloxy)-2,4-dimethylhex-4-en-1-ol 在 sodium tetrahydroborate 、 重铬酸吡啶 、 nickel(II) chloride hexahydrate 、 sodium ethanolate 、 二异丁基氢化铝 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 0.83h， 生成 (4R,5R,E)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethyloct-6-enal
  参考文献：
  名称：

  Accessing the Structural Diversity of Pyridone Alkaloids: Concise Total Synthesis of Rac-Citridone A

  摘要：

  A unique route to the structural diversity of pyridone alkaloids is described based on the concept of a common synthetic strategy. Three different core structure analogues corresponding to akanthomycin, septoriamycin A, and cltridone A have been prepared by using a highly selective and novel carbocyclization reaction.

  DOI：

  10.1021/ol2017802

文献信息

• Accessing the Structural Diversity of Pyridone Alkaloids: Concise Total Synthesis of <i>Rac</i>-Citridone A
  作者：Anna D. Fotiadou、Alexandros L. Zografos

  DOI：10.1021/ol2017802

  日期：2011.9.2

  A unique route to the structural diversity of pyridone alkaloids is described based on the concept of a common synthetic strategy. Three different core structure analogues corresponding to akanthomycin, septoriamycin A, and cltridone A have been prepared by using a highly selective and novel carbocyclization reaction.