1-N-(3'-C-allyl-5'-O-trityl-2'-deoxy-β-D-xylofuranosyl)thymine | 1112393-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-N-(3'-C-allyl-5'-O-trityl-2'-deoxy-β-D-xylofuranosyl)thymine
• 英文别名: 1-[(2R,4R,5R)-4-hydroxy-4-prop-2-enyl-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 1112393-11-9
• 化学式: C₃₂H₃₂N₂O₅
• 分子量: 524.616
• InChiKey: HQDWTHKDLNRJJX-QIBDARBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-N-(3'-C-allyl-5'-O-trityl-2'-deoxy-β-D-xylofuranosyl)thymine 、 溴甲苯 在 sodium hydride 作用下， 以 四氢呋喃 、 oil 为溶剂， 反应 1.0h， 以80%的产率得到1N-(3'-C-allyl-3'-O-benzyl-5'-O-trityl-2'-deoxy-β-D-xylofuranosyl)thymine
  参考文献：
  名称：

  Synthesis of Bicyclic 2′-Deoxynucleosides with α-l-ribo- and β-d-xylo-Configurations and Restricted S- and N-Type Conformations

  摘要：

  Two bicyclic 2'-deoxynucleoside analogues are synthesized in 12 steps each from thymidine. With a six-membered ring fused to the C3'-C4' bond and an alpha-L-ribo- and a beta-D-xylo-configuration, these are con formationally restricted in an S- and an N-type conformation, respectively. The constitutions were proven by X-ray crystallography. ne beta-D-xylo-configured analogue is successfully converted to a 3'-phosphoramidite and incorporated into oligodeoxynucleotides, which are found to hybridize to DNA and RNA complements with decreased affinity.

  DOI：

  10.1021/jo8023472
• 作为产物：
  描述：

  3'-keto-5'-O-tritylthymidine 、 烯丙基溴化镁 在 cerium(III) chloride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 17.0h， 以1.78 g的产率得到1-N-(3'-C-allyl-5'-O-trityl-2'-deoxy-β-D-xylofuranosyl)thymine
  参考文献：
  名称：

  Synthesis of Bicyclic 2′-Deoxynucleosides with α-l-ribo- and β-d-xylo-Configurations and Restricted S- and N-Type Conformations

  摘要：

  Two bicyclic 2'-deoxynucleoside analogues are synthesized in 12 steps each from thymidine. With a six-membered ring fused to the C3'-C4' bond and an alpha-L-ribo- and a beta-D-xylo-configuration, these are con formationally restricted in an S- and an N-type conformation, respectively. The constitutions were proven by X-ray crystallography. ne beta-D-xylo-configured analogue is successfully converted to a 3'-phosphoramidite and incorporated into oligodeoxynucleotides, which are found to hybridize to DNA and RNA complements with decreased affinity.

  DOI：

  10.1021/jo8023472

文献信息

• Synthesis of Bicyclic 2′-Deoxynucleosides with α-<scp>l</scp>-<i>ribo</i>- and β-<scp>d</scp>-<i>xylo</i>-Configurations and Restricted <i>S</i>- and <i>N</i>-Type Conformations
  作者：Khalil I. Shaikh、Surender Kumar、Lene Lundhus、Andrew D. Bond、Pawan K. Sharma、Poul Nielsen

  DOI：10.1021/jo8023472

  日期：2009.2.20

  Two bicyclic 2'-deoxynucleoside analogues are synthesized in 12 steps each from thymidine. With a six-membered ring fused to the C3'-C4' bond and an alpha-L-ribo- and a beta-D-xylo-configuration, these are con formationally restricted in an S- and an N-type conformation, respectively. The constitutions were proven by X-ray crystallography. ne beta-D-xylo-configured analogue is successfully converted to a 3'-phosphoramidite and incorporated into oligodeoxynucleotides, which are found to hybridize to DNA and RNA complements with decreased affinity.