8H-Purin-8-one, 7-(2-butynyl)-7,9-dihydro-9-(6-methoxy-3-pyridinyl)-6-(1-piperazinyl)- | 705300-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8H-Purin-8-one, 7-(2-butynyl)-7,9-dihydro-9-(6-methoxy-3-pyridinyl)-6-(1-piperazinyl)-
• 英文别名: 7-but-2-ynyl-9-(6-methoxypyridin-3-yl)-6-piperazin-1-ylpurin-8-one
• CAS: 705300-19-2
• 化学式: C₁₉H₂₁N₇O₂
• 分子量: 379.4
• InChiKey: DKHHDEIZLVCHEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2281069A2

  公开（公告）日：2011-02-09
• Methods For Identifying Patients With An Increased Likelihood Of Responding To DPP-IV Inhibitors
  申请人：Koustubh Ranade

  公开号：US20110020797A1

  公开（公告）日：2011-01-27

  The invention provides novel in vitro diagnostic methods for identifying patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides, which comprise at least one polymorphic locus per fragment, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis.
• Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors
  申请人：Emison Eileen

  公开号：US20110152340A1

  公开（公告）日：2011-06-23

  The invention provides novel in vitro diagnostic methods for identifying subjects or patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments which comprise at least one polymorphic locus, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the invention are useful in phenotype correlations, medicine, and genetic analysis.
• US7524847B2
  申请人：——

  公开号：US7524847B2

  公开（公告）日：2009-04-28
• [EN] METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS<br/>[FR] PROCÉDÉS POUR L'IDENTIFICATION DE PATIENTS AYANT UNE FORTE PROBABILITÉ DE RÉAGIR AUX INHIBITEURS DE DPP-IV
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2008098256A1

  公开（公告）日：2008-08-14

  [EN] The invention provides novel in vitro diagnostic methods for identifying patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides, which comprise at least one polymorphic locus per fragment, are also provided. Allele- specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis.
  [FR] L'invention concerne de nouveaux procédés de diagnostic in vitro pour l'identification de patients qui peuvent présenter une forte probabilité de réaction à une thérapie d'inhibiteurs de DPP-IV. L'invention propose également de nouveaux polynucléotides associés à la réaction accrue d'un patient à l'inhibition de DPP-IV. Des fragments de polynucléotides correspondant aux régions génomiques et/ou de codage de ces polynucléotides, qui comprennent au moins un locus polymorphe par fragment, sont également proposés. Des amorces et des sondes qui hybrident au niveau de ces régions polymorphes et/ou qui comprennent au moins un locus polymorphe sont également proposées. Les polynucléotides, les amorces et les sondes de la présente invention sont utiles dans les corrélations du phénotype, la médecine et l'analyse génétique.