1-phenylacenaphthylene | 4044-56-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 吖萘类
• 英文名称: 1-phenylacenaphthylene
• 英文别名: 1-phenyl-acenaphthylene；1-Phenyl-acenaphthylen；1-Phenylacenaphthylen；2-Phenylphenanthren
• CAS: 4044-56-8
• 化学式: C₁₈H₁₂
• 分子量: 228.293
• InChiKey: RGYRCSKRQNNKOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2902909090

反应信息

• 作为反应物：
  描述：

  1-phenylacenaphthylene 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 8-苯甲酰基萘-1-羧酸
  参考文献：
  名称：

  Ghigi, Chemische Berichte, 1940, vol. 73, p. 677,686

  摘要：

  DOI：
• 作为产物：
  描述：

  1-苊酮 在 溶剂黄146 作用下， 生成 1-phenylacenaphthylene
  参考文献：
  名称：

  540.在庚ign中添加格氏试剂

  摘要：

  DOI：

  10.1039/jr9630002905

文献信息

• Ap-benzyne tom-benzyne conversion through a 1,2-shift of a phenyl group. Completion of the benzyne cascade
  作者：Alexei L. Polishchuk、Kevin L. Bartlett、Lee A. Friedman、Maitland Jones

  DOI：10.1002/poc.797

  日期：2004.9

  5-diyne-cis-3-ene at 800–1000°C leads to a mixture of 1- and 2-phenylbiphenylene, along with triphenylene. Formation of the two biphenylenes is taken as strong evidence of the rearrangement of a p-benzyne into a m-benzyne through a shift of one of the phenyl groups. Copyright © 2004 John Wiley & Sons, Ltd.

  1,6- diphenylhexa -1,5- diyne-热解顺式-3-烯在800-1000℃通入1-和2- phenylbiphenylene的混合物，用菲沿。两个亚联的形成被取为一个的重新安排的强有力的证据p -benzyne成米通过苯基基团中的一个的移位-benzyne。版权所有©2004 John Wiley＆Sons，Ltd.
• Rhodium-Catalyzed Coupling Reaction of Aroyl Chlorides with Alkenes
  作者：Toru Sugihara、Tetsuya Satoh、Masahiro Miura、Masakatsu Nomura

  DOI：10.1002/adsc.200404145

  日期：2004.12

  Aroyl chlorides react with acyclic and cyclic alkenes in the presence of a rhodium catalyst to give Mizoroki–Heck type and cyclization products, respectively. A rhodium-ethylene complex, [RhCl(C2H4)2}2], showed excellent performance for these reactions. Notably, the reactions can be conducted effectively under base- and phosphane-free conditions.

  在铑催化剂的存在下，芳酰氯与无环和环状烯烃反应，分别得到Mizoroki-Heck型和环化产物。铑-乙烯络合物[RhCl（C 2 H 4）2 } 2 ]显示出对于这些反应的优异性能。值得注意的是，该反应可以在无碱和无膦的条件下有效地进行。
• Ozonide compounds with inhibitory activity for urokinase production and angiogenesis
  申请人：Taiho Pharmaceutical Company Ltd.

  公开号：US06365610B1

  公开（公告）日：2002-04-02

  The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom or N—R (wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom); B is an oxo group or —R4; and (1) when A is an oxygen atom, R1 is a hydrogen atom, etc., R2 is phenyl, etc., R3 is a hydrogen atom, etc., B is an oxo group or —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.; (2) when A is N—R, R1 is a hydrogen atom, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., B is —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.

  该发明提供了一种尿激酶产生抑制剂或血管生成抑制剂，其包括作为活性成分的一种由式（1）表示的臭氧化物衍生物，以及使用该抑制剂的预防或治疗方法，其中A是氧原子或N—R（其中R是苯基或苯基，其取代基为1至6个碳原子的较低烷基，1至6个碳原子的较低烷氧基或卤原子）；B是羰基或—R4；当A是氧原子时，R1是氢原子等，R2是苯基等，R3是氢原子等，B是羰基或—R4，R4是氢原子等，R5是氢原子等；当A是N—R时，R1是氢原子等，R2是氢原子等，R3是氢原子等，B是—R4，R4是氢原子等，R5是氢原子等。
• The Oxyphenylation of Cyclic Olefins Conjugated to the Benzene Ring by Means of Palladium Chloride
  作者：Hiroshi Horino、Mannosuke Arai、Naoto Inoue

  DOI：10.1246/bcsj.47.1683

  日期：1974.7

  reaction of 1,2-dihydronaphthalene, indene, and acenaphthylene with phenylpalladium chloride prepared in situ from phenylmercuric chloride and lithium chloropalladate in aqueous acetone afforded 2-phenyltetrarol, 2-phenylindanol, and 2-phenylacenaphthenol respectively, accompanying by the corresponding phenylated olefins. Acetoxyphenylation products were also obtained in the reactions in acetic acid.

  1,2-二氢萘、茚和苊与由氯化苯汞和氯钯酸锂在丙酮水溶液中原位制备的苯基氯化钯反应，分别得到 2-苯基四醇、2-苯基茚满醇和 2-苯基苊醇，以及相应的苯基化烯烃。在乙酸中的反应中也得到乙酰氧基苯基化产物。这些氧苯基化合物的构型被确定为反式。
• 284. Syntheses of some asymmetric naphthalene and acenaphthene hydrocarbons
  作者：B. R. Brown、D. Ll. Hammick

  DOI：10.1039/jr9480001395

  日期：——