sodium piperidinedithiocarbamate | 29053-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: sodium piperidinedithiocarbamate
• 英文别名: sodium piperidin-1-ylcarbamodithioate；Sodium;dithiocarboxy(piperidin-1-yl)azanide；sodium;dithiocarboxy(piperidin-1-yl)azanide
• CAS: 29053-42-7
• 化学式: C₆H₁₁N₂S₂*Na
• 分子量: 198.289
• InChiKey: NCPGFELEEWBSRW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.19
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  48.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-氯乙基)吗啉 、 sodium piperidinedithiocarbamate 以 水 为溶剂， 反应 0.5h， 以70%的产率得到2-(morpholin-4-yl)ethyl piperidin-1-ylcarbamodithioate
  参考文献：
  名称：

  Design and synthesis of substituted morpholin/piperidin-1-yl-carbamodithioates as promising vaginal microbicides with spermicidal potential

  摘要：

  A series of seventeen morpholin/piperidin-1-yl-carbamodithioate (3-19) were synthesized as topical vaginal microbicidal spermicides. The synthesized compounds were evaluated for their anti-Trichomonas activity against MTZ susceptible and resistant strains along with their spermicidal and antifungal potential. All the synthesized compounds were assessed for their safety through cytotoxic assay against human cervical cell line (HeLa) and compatibility with vaginal flora, Lactobacillus. The study identified eleven dually active compounds with apparent safety. The plausible mode of action of these compounds was through sulfhydryl binding, confirmed via reduction in available free thiols on human sperm. The most promising compound 9 significantly inhibited (P < 0.001) thiol-sensitive sperm hexokinase. The stability of compound 9 in simulated vaginal fluid (SVF) was performed via HPLC-PDA method, which supported its utility for vaginal administration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.040
• 作为产物：
  描述：

  二硫化碳 、 1-氨基哌啶 在 sodium hydroxide 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 3.0h， 以93.5%的产率得到sodium piperidinedithiocarbamate
  参考文献：
  名称：

  Design and synthesis of substituted morpholin/piperidin-1-yl-carbamodithioates as promising vaginal microbicides with spermicidal potential

  摘要：

  A series of seventeen morpholin/piperidin-1-yl-carbamodithioate (3-19) were synthesized as topical vaginal microbicidal spermicides. The synthesized compounds were evaluated for their anti-Trichomonas activity against MTZ susceptible and resistant strains along with their spermicidal and antifungal potential. All the synthesized compounds were assessed for their safety through cytotoxic assay against human cervical cell line (HeLa) and compatibility with vaginal flora, Lactobacillus. The study identified eleven dually active compounds with apparent safety. The plausible mode of action of these compounds was through sulfhydryl binding, confirmed via reduction in available free thiols on human sperm. The most promising compound 9 significantly inhibited (P < 0.001) thiol-sensitive sperm hexokinase. The stability of compound 9 in simulated vaginal fluid (SVF) was performed via HPLC-PDA method, which supported its utility for vaginal administration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.040

文献信息

• Technetium or rhenium complexes, radiopharmaceutical products comprising them
  申请人：Mevellec Franck

  公开号：US20050008568A1

  公开（公告）日：2005-01-13

  The invention relates to a technetium or rhenium complex of formula (I): [M (R 1 CS 3 ) 2 L]  (I) in which M is Tc or Re, R 1 represents an alkyl, cycloalkyl, aralkyl or aryl group which is unsubstituted or substituted by one or more substituents chosen from halogen atoms, the hydroxyl group, alkyl groups and alkoxy groups, and L is a dithiolate ligand, with the exception of the ligand of formula R 2 CS 2 in which R 2 is identical to R 1 . The dithiolate ligand is preferably a dithiocarbamate. The invention also relates to a radiopharmaceutical product comprising a complex of formula (I) with M representing 99 Tc, 186 Re or 188 Re.

  该发明涉及公式（I）的锝或铼配合物： [M（R 1 CS 3 ） 2 L]  （I） 其中M为Tc或Re，R 1 代表未取代或取代为一个或多个卤素原子、羟基、烷基和烷氧基中的一种取代基的烷基、环烷基、芳基或芳基，L为二硫醚配体，但不包括公式R 2 CS 2 中R 2 与R 1 相同的配体。 该二硫醚配体优选为二硫代氨基甲酸酯。 该发明还涉及包含公式（I）中M代表 99 Tc、 186 Re或 188 Re的放射性药物产品。
• Development of molecular precursors for deposition of indium sulphide thin film electrodes for photoelectrochemical applications
  作者：Muhammad Ali Ehsan、T. A. Nirmal Peiris、K. G. Upul Wijayantha、Marilyn M. Olmstead、Zainudin Arifin、Muhammad Mazhar、K. M. Lo、Vickie McKee

  DOI：10.1039/c3dt50781e

  日期：——

  Symmetrical and unsymmetrical dithiocarbamato pyridine solvated and non-solvated complexes of indium(III) with the general formula [In(S2CNRR′)3]·n(py) [where py = pyridine; R,R′ = Cy, n = 2 (1); R,R′ = iPr, n = 1.5 (2); NRR′ = Pip, n = 0.5 (3) and R = Bz, R′ = Me, n = 0 (4)] have been synthesized. The compositions, structures and properties of these complexes have been studied by means of microanalysis, IR and 1H-NMR spectroscopy, X-ray single crystal and thermogravimetric (TG/DTG) analyses. The applicability of these complexes as single source precursors (SSPs) for the deposition of β-In2S3 thin films on fluorine-doped SnO2 (FTO) coated conducting glass substrates by aerosol-assisted chemical vapour deposition (AACVD) at temperatures of 300, 350 and 400 °C is studied. All films have been characterized by powder X-ray diffraction (PXRD) and energy dispersive X-ray analysis (EDX) for the detection of phase and stoichiometry of the deposit. Scanning electron microscopy (SEM) studies reveal that precursors (1)–(4), irrespective of different metal ligand design, generate comparable morphologies of β-In2S3 thin films at different temperatures. Direct band gap energies of 2.2 eV have been estimated from the UV-vis spectroscopy for the β-In2S3 films fabricated from precursors (1) and (4). The photoelectrochemical (PEC) properties of β-In2S3 were confirmed by recording the current–voltage plots under light and dark conditions. The plots showed anodic photocurrent densities of 1.25 and 0.65 mA cm−2 at 0.23 V vs. Ag/AgCl for the β-In2S3 films made at 400 and 350 °C from the precursors (1) and (4), respectively. The photoelectrochemical performance indicates that the newly synthesised precursors are highly useful in fabricating β-In2S3 electrodes for solar energy harvesting and optoelectronic application.

  通式为 [In(S2CNRR′)3]-n(py) [其中 py = 吡啶；R,R′ = Cy，n = 2 (1)；R,R′ = iPr，n = 1.5 (2); NRR′ = Pip, n = 0.5 (3) 和 R = Bz, R′ = Me, n = 0 (4)] 已被合成。通过显微分析、红外光谱和 1H-NMR 光谱、X 射线单晶和热重（TG/DTG）分析，对这些复合物的组成、结构和性质进行了研究。研究了这些复合物作为单源前驱体 (SSP) 在 300、350 和 400 °C 温度下通过气溶胶辅助化学气相沉积 (AACVD) 在氟掺杂 SnO2 (FTO) 涂层导电玻璃基底上沉积 β-In2S3 薄膜的适用性。所有薄膜都通过粉末 X 射线衍射 (PXRD) 和能量色散 X 射线分析 (EDX) 进行了表征，以检测沉积物的相位和化学计量。扫描电子显微镜（SEM）研究表明，前驱体（1）-（4），无论金属配体设计如何，在不同温度下生成的 β-In2S3 薄膜形貌相当。根据紫外-可见光谱，前体（1）和（4）制备的 β-In2S3 薄膜的直接带隙能估计为 2.2 eV。通过记录光照和黑暗条件下的电流-电压图，证实了 β-In2S3 的光电化学（PEC）特性。图中显示，在 0.23 V 电压下，以前驱体 (1) 和 (4) 为原料在 400 ℃ 和 350 ℃ 制成的 β-In2S3 薄膜对 Ag/AgCl 的阳极光电流密度分别为 1.25 和 0.65 mA cm-2。光电化学性能表明，新合成的前驱体在制造用于太阳能收集和光电应用的 β-In2S3 电极方面非常有用。
• Vasanthi, S.; Nagaraja, K. S., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1984, vol. 23, # 1, p. 70 - 71
  作者：Vasanthi, S.、Nagaraja, K. S.

  DOI：——

  日期：——
• Synthesis and spectroscopic characterization of triphenylphosphine oxide adducts of uranyl dithiocarbamates
  作者：C.C. Hadjikostas、G.A. Katsoulos、M.P. Sigalas

  DOI：10.1016/s0020-1693(00)84474-6

  日期：1987.11
• TECHNETIUM OR RHENIUM COMPLEXES, RADIOPHARMACEUTICAL PRODUCTS COMPRISING THEM
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP1453841A1

  公开（公告）日：2004-09-08