2-(N,N-dimethylamino)ethyl methyl carbonate | 20570-41-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 2-(N,N-dimethylamino)ethyl methyl carbonate
• 英文别名: 2-(dimethylamino)ethyl methyl carbonate；Methyl-(2-dimethylamino-ethyl)-carbonat；Carbonic acid, 2-dimethylaminoethyl methyl ester
• CAS: 20570-41-6
• 化学式: C₆H₁₃NO₃
• 分子量: 147.174
• InChiKey: HPEDSAAIRIGVPE-UHFFFAOYSA-N

物化性质

• 沸点：
  51 °C(Press: 1.5 Torr)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-叔丁基苯酚 、 2-(N,N-dimethylamino)ethyl methyl carbonate 以 乙腈 为溶剂， 反应 0.12h， 以98%的产率得到2-(2-(tert-butyl)phenoxy)-N,N-dimethylethanamine
  参考文献：
  名称：

  通过芥子碳酸盐类似物的微波辅助氨基烷基化酚类

  摘要：

  提出了一种微波辅助无氯直接苯酚取代，被认为是制药商的一个重点绿色化学研究领域。在极性溶剂（乙腈或丁醇）存在下，β-氨基碳酸酯（芥子碳酸酯）与几种取代酚的反应通过有机碳酸酯骨架中氮的非嵌合辅助产生相关的氨基烷基化产物。氨基烷基化反应需要很短的反应时间（7 分钟），并且通过快速液-液萃取或柱色谱法以高产率（>90%）分离相关产物，具体取决于所用溶剂。此外，微波辐射还以优异的收率促进了苯酚的一锅氨烷基化。在这种方法中，β-氨基醇与苯酚在碳酸二乙酯存在下反应，用于原位形成 β-氨基碳酸酯，这是随后的非嵌合驱动烷基化的关键中间体。由此产生的产品，即N，N-二甲基-2-苯氧基乙胺以几乎定量的收率分离为纯品。

  DOI：

  10.1055/a-1742-3723
• 作为产物：
  描述：

  N,N-二甲基乙醇胺 、 氯甲酸甲酯 以 苯 为溶剂， 生成 2-(N,N-dimethylamino)ethyl methyl carbonate
  参考文献：
  名称：

  Vieles,P.; Galsomias,J., Bulletin de la Societe Chimique de France, 1968, p. 461 - 462

  摘要：

  DOI：

文献信息

• Sulfur and Nitrogen Mustard Carbonate Analogues
  作者：Fabio Aricò、Matteo Chiurato、Josephine Peltier、Pietro Tundo

  DOI：10.1002/ejoc.201200321

  日期：2012.6

  Sulfur and nitrogen half-mustard compounds lose their aggressive properties when the chlorine atom is replaced by a carbonate moiety. The anchimeric effect of the novel mustard carbonate analogues is investigated. The reaction follows first-order kinetics, does not need any base, and occurs with –OH, –NH and acidic –CH nucleophiles. Most of these molecules are unexplored and might provide a novel strategy

  当氯原子被碳酸酯部分取代时，硫和氮半芥子气化合物失去其侵蚀性。研究了新型芥菜碳酸盐类似物的嵌合效应。该反应遵循一级动力学，不需要任何碱，并与 -OH、-NH 和酸性 -CH 亲核试剂一起发生。这些分子中的大多数是未经探索的，可能为制备以前不易获得的化合物提供一种新的策略。
• Lipids and lipid compositions for the delivery of active agents
  申请人：Novartis AG

  公开号：US10729775B2

  公开（公告）日：2020-08-04

  This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

  本发明提供了一种式 (I) 的化合物： 或其药学上可接受的盐，其中 R1-R4、L 和 X 在本文中定义。式（I）化合物及其药学上可接受的盐是阳离子脂质，可用于向细胞和组织递送生物活性剂。
• Electrochemical fluorination of (N,N-dialkylamino)alcohols
  作者：Takashi Abe、Haruhiko Fukaya、Eiji Hayashi、Taizo Ono、Masakazu Nishida、Irina Soloshonok、Kunio Okuhara

  DOI：10.1016/s0022-1139(99)00053-6

  日期：1999.7

  Series of amino alcohols including 2-(N,N-dialkylamino)ethanols, 3-(N,N-dimethylamino)propanol and 4-(N,N-dimethylamino)butanol were subjected to electrochemical fluorination. In the case of 2-(N,N-dialkylamino)ethanols, the F-(2-N, N-dialkylamino) acetyl fluorides were obtained in fair to good yields. Yields of each target compound were strongly dependent on the kind of the dialkylamino group. Cyclic amines having an N-(2-hydroxylethyl) group afforded the corresponding F-[N-(c-alkylamino)-substituted acetyl fluorides]. Their yields were generally better than those of acyclic analogs. Several 2-(N,N-dialkylamino)ethanols and 3-(N,N-dimethylamino)propanol were converted into the corresponding trimethylsilylethers, aminoalkyl methyl carbonates and bis-aminoalkyl carbonate, respectively, and they were subjected to fluorination for a comparison of the yield with that obtained from that of the parent aminoalcohol. (C) 1999 Elsevier Science S.A. All rights reserved.
• SUZUKI, AKINORI;HYCON, SUONG B.;KAJITA, TOSHIO;FURUSHIMA, MASAKAZU;YOSHIN+
  作者：SUZUKI, AKINORI、HYCON, SUONG B.、KAJITA, TOSHIO、FURUSHIMA, MASAKAZU、YOSHIN+

  DOI：——

  日期：——
• METHOD OF ENCAPSULATING A NUCLEIC ACID IN A LIPID NANOPARTICLE HOST
  申请人：BOWMAN Keith A.

  公开号：US20170196809A1

  公开（公告）日：2017-07-13

  Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.