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    首页 分子通 (2R,6R,7R,8S,11R)-11-phenyl-7-[(E)-2-phenylethenyl]-10-thia-1-azatricyclo[6.3.0.02,6]undecan-5-one

    (2R,6R,7R,8S,11R)-11-phenyl-7-[(E)-2-phenylethenyl]-10-thia-1-azatricyclo[6.3.0.02,6]undecan-5-one | 131570-74-6

    分子结构分类

    有机化合物 - 有机杂环化合物 - 吡咯并噻唑
    中文名称
    ——
    中文别名
    ——
    英文名称
    (2R,6R,7R,8S,11R)-11-phenyl-7-[(E)-2-phenylethenyl]-10-thia-1-azatricyclo[6.3.0.02,6]undecan-5-one
    英文别名
    ——
    (2R,6R,7R,8S,11R)-11-phenyl-7-[(E)-2-phenylethenyl]-10-thia-1-azatricyclo[6.3.0.02,6]undecan-5-one化学式
    CAS
    131570-74-6
    化学式
    C23H23NOS
    mdl
    ——
    分子量
    361.508
    InChiKey
    KSWXYNSDVANBGG-RCJDHPLNSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      4.5
    • 重原子数：
      26
    • 可旋转键数：
      3
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.35
    • 拓扑面积：
      45.6
    • 氢给体数：
      0
    • 氢受体数：
      3

    反应信息

    点击查看最新优质反应信息

    文献信息

    • Intramolecular Cycloaddition of the Azomethine Ylides Derived from α-Amino Acids or Esters and 5-Oxo-6-heptenals or 4-Oxo-5-hexenals
      作者：Shuji Kanemasa、Kenji Doi、Eiji Wada
      DOI：10.1246/bcsj.63.2866
      日期：1990.10
      Intramolecular cycloadditions of the azomethine ylides bearing a carbonyl-activated olefinic moiety, generated from α-amino acids or esters and 5-oxo-6-heptenals or 4-oxo-5-hexenals, produce the stereoselective internal cycloadducts either to olefin or carbonyl dipolarophilic function with normal or inverse regioselectivity, depending upon the types of ylides as well as the intervening chain length
      由α-氨基酸或酯和5-氧-6-庚烯醛或4-氧-5-己烯醛产生的带有羰基活化的烯烃部分的偶氮甲碱叶立德的分子内环加成，产生到烯烃或羰基亲二极体的立体选择性内环加合物功能具有正常或反向区域选择性，取决于叶立德的类型以及中间链长。当使用 2-苯基-4-噻唑烷羧酸及其甲酯时，已经实现了极高的非对映面选择性。
    • KANEMASA, SHUJI;DOI, KENJI;WADA, EIJI, BULL. CHEM. SOC. JAP., 63,(1990) N0, C. 2866-2871
      作者：KANEMASA, SHUJI、DOI, KENJI、WADA, EIJI
      DOI：——
      日期：——
    查看更多

    同类化合物

    4H-吡咯并[2.3-d][1,3]噻唑-5-羧酸乙酯 4H-吡咯并[2,3-d]噻唑-5-羧酸 4H-吡咯并[2,3-d]噻唑 (7aS)-1-(1-cyanoethenyl)tetrahydro-1H,3H-pyrrolo[1,2-c]thiazole-3-thione 4-methyl-4,6-dihydro-5H-thiazolo[5‘,4‘:4,5]pyrrolo[2,3-d]pyridazin-5-one 3-((2,4-dimethyl-5-oxo-4H-thiazolo[5’,4’:4,5]pyrrolo[2,3-d]pyridazin-6(5H)-yl)methyl)benzonitrile 7-propyl-7H-3,4-dithia-1,6,7-triazacyclopenta[a]pentalene 7-propyl-2,5-bis(trimethylstannyl)-7H-3,4-dithia-1,6,7-triazacyclopenta[a]pentalene 4-methyl-4H-pyrrolo[2,3-d]thiazole-5-carboxylic acid 3-morpholino-4-(2,4,5-trimethyl-4H-pyrrolo[3,2-d][1,3]thiazol-6-yl)cyclobut-3-ene-1,2-dione (S)-3-thia-1-azabicyclo[3.3.0]octan-2-one 3,3-dioxide methyl 4H-pyrrolo[2,3-d]thiazole-5-carboxylate (4H-pyrrolo[2,3-d]thiazol-5-yl)methanol 5-methyl-4H-pyrrolo[2,3-d]thiazole tert-butyl 2-amino-4H-pyrrolo[3,2-d]thiazole-4-carboxylate 2-ethoxycarbonylamino-4-methyl-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid methyl ester (4-methyl-6-nitro-4H-pyrrolo[2,3-d]thiazol-2-yl)-carbamic acid ethyl ester 2-ethoxycarbonylamino-4-methyl-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid ethyl ester (5-bromo-4-methyl-6-nitro-4H-pyrrolo[3,2-d]thiazol-2-yl)-carbamic acid ethyl ester 2-Ethoxycarbonylamino-4-methylpyrrolo<3,2-d>thiazol (Z)-2-[(methylsulfonyl)methylidene]pyrrolidino[2,1-c]thiazolidine (5-bromo-4-methyl-6-nitro-4H-pyrrolo[2,3-d]thiazol-2-yl)-carbamic acid ethyl ester ethyl 2-methyl-4H-pyrrolo[3,2-d]thiazole-5-carboxylate ethyl 5-methyl-5H-pyrrolo[3,4-d]thiazolo-2-carboxylate 2-phenyl-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid ethyl ester 5-benzyl-4H-pyrrolo[2,3-d]thiazole 4-(4H-pyrrolo[2,3-d]thiazol-5-yl)pyridin-2-ylamine ethyl 4H-pyrrolo[3,2-d]thiazole-5-carboxylate 2,6-dibromo-4-(2-octyldodecyl)-4H-pyrrolo[3,2-d:4,5-d]bisthiazole tetrahydro-pyrrolo[1,2-c]thiazole-3-thione (-)-(1R,7aS)-1-methyltetrahydropyrrolo[1,2-c]thiazol-3(1H)-thione (-)-(1S,7aS)-1-methyltetrahydropyrrolo[1,2-c]thiazol-3(1H)-thione methyl (2R,6R,7R,8S,11R)-5-oxo-11-phenyl-10-thia-1-azatricyclo[6.3.0.02,6]undecane-7-carboxylate (2R,6R,7R,8S,11R)-11-phenyl-7-[(E)-2-phenylethenyl]-10-thia-1-azatricyclo[6.3.0.02,6]undecan-5-one N-[[4-(propan-2-ylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxamide N-[[4-(pyridin-2-ylmethylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxamide N-[[4-(morpholine-4-carbonyl)cyclohexyl]methyl]-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxamide N-[[4-(thiophen-2-ylmethylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxamide N-[[4-(pyridin-2-ylmethylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide N-[[4-(morpholine-4-carbonyl)cyclohexyl]methyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide N-[[4-(cyclopropylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide N-[[4-(furan-2-ylmethylcarbamoyl)cyclohexyl]methyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide N-[[4-(pyrrolidine-1-carbonyl)cyclohexyl]methyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide (1S,2S,7S,8R)-10-[2-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]-7-[(E)-2-phenylethenyl]-4-thia-6,10-diazatricyclo[6.3.0.02,6]undecane-9,11-dione (1S,2S,7R,8R)-10-[2-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]-7-[(E)-2-phenylethenyl]-4-thia-6,10-diazatricyclo[6.3.0.02,6]undecane-9,11-dione 4-[(3,4-Dichlorophenyl)methyl]pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid 2-(4H-pyrrolo[2,3-d][1,3]thiazol-5-yl)acetic acid Methyl 4-(3,4-dichlorobenzyl)-2-methyl-4 H-pyrrolo[3,2-d ][1,3]thiazole-5-carboxylate Ethyl 4-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d][1,3]thiazole-5-carboxylate methyl 4-(3,4-dichlorobenzyl)-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylate

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