2-[二(4-二甲胺苯基)甲基]-4-氯-苯酚 | 6310-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: 2-[二(4-二甲胺苯基)甲基]-4-氯-苯酚
• 英文名称: 2-[bis[4-(dimethylamino)phenyl]methyl]-4-chlorophenol
• CAS: 6310-63-0
• 化学式: C₂₃H₂₅ClN₂O
• 分子量: 380.917
• InChiKey: GNAGPLJSQBXRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基苯胺 、 5-氯代水杨醛 在 五氯化铌 作用下， 反应 1.0h， 以83%的产率得到2-[二(4-二甲胺苯基)甲基]-4-氯-苯酚
  参考文献：
  名称：

  An efficient and convenient protocol for the synthesis of diaminotriarylmethanes

  摘要：

  A novel and efficient procedure was developed for the preparation of diaminotriarylmethanes through the Baeyer condensation of aromatic aldehydes and N,N-dimethylaniline or N,N-diethylaniline in the presence of niobium chloride under solvent-free conditions. This approach offers several advantages, such as short reaction time, high yields, low cost, and mild reaction conditions.

  DOI：

  10.1007/s00706-011-0461-2

文献信息

• An efficient and convenient protocol for the synthesis of diaminotriarylmethanes
  作者：Jun-Tao Hou、Jian-Wu Gao、Zhan-Hui Zhang

  DOI：10.1007/s00706-011-0461-2

  日期：2011.5

  A novel and efficient procedure was developed for the preparation of diaminotriarylmethanes through the Baeyer condensation of aromatic aldehydes and N,N-dimethylaniline or N,N-diethylaniline in the presence of niobium chloride under solvent-free conditions. This approach offers several advantages, such as short reaction time, high yields, low cost, and mild reaction conditions.