5-benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one | 15788-42-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one
• 英文别名: 5-benzylidene-2-piperidino-1,3-thiazol-4(5H)-one；5-Benzylidene-4-oxo-2-piperidino-2-thiazoline；5-benzylidene-2-piperidin-1-yl-thiazol-4-one；5-Benzyliden-2-piperidino-2-thiazolin-4-on；4(5H)-Thiazolone, 5-(phenylmethylene)-2-(1-piperidinyl)-；5-benzylidene-2-piperidin-1-yl-1,3-thiazol-4-one
• CAS: 15788-42-8
• 化学式: C₁₅H₁₆N₂OS
• 分子量: 272.371
• InChiKey: MMGHNCMUHOPXJY-UHFFFAOYSA-N

物化性质

• 熔点：
  202-204 °C(Solv: toluene (108-88-3); ethanol (64-17-5))
• 沸点：
  421.9±48.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one 在 氢氧化钾 、 氯乙酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 5-benzylidene-2,4-thiazolidinedione
  参考文献：
  名称：

  Omar, M. T.; Habashy, M. M.; Kasem, M. A., Journal fur praktische Chemie (Leipzig 1954), 1982, vol. 324, # 3, p. 483 - 487

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 5-(苯基亚甲基)-2-硫氧代-4-噻唑啉酮 以 乙醇 为溶剂， 以80%的产率得到5-benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one
  参考文献：
  名称：

  Studies On Some Thiazolidinones As Antioxidants For Local Base Oil

  摘要：

  IN THIS work, 5 thiazolidinone derivatives of the type 5-benzylidene-2-(1-piperidinyl)4-oxo-1,3-thiazolidine (101), 5-(4-butoxybenzylidene)-2-(1-piperidinyl)-4-oxo-1,3-thiazolidine (102), 5-(4-hexyloxybenzylidene)-2-(1-piperidinyl)-4-oxo-1,3-thiazolidine (103), 5-(4-octyloxybenzylidene)-2-(1-piperidinyl)-4-oxo-1,3-thiazolidine (104) and 5-(4-decyloxybenzylidene)-2-(1-piperidinyl)-4-oxo-1,3-thiazolidine (105) are synthesized and characterized using conventional tools analyses. They are tested as antioxidants for local base stock and the efficiency of these compounds, as antioxidants, was monitored through studying the change in total acid number and viscosity, the results reveal that the efficiency order is ranked as follows 105 > 104 > 103 > 102 > 101. The quantum chemical parameters such as the lowest unoccupied molecular orbital (LUMO), the highest occupied molecular orbital (HOMO) energy levels and the energy gap (E-HOMO-E-LUMO) were calculated. The experimental results were on the same line with the quantum chemical calculations.

  DOI：

  10.21608/ejchem.2019.6662.1560

文献信息

• Formation of ionic carbon nitride towards an environmentally friendly synthesis of 2-amino-5-alkylidene-thiazol-4-one
  作者：Najmedin Azizi、Navid Habibnejad、Tahereh Soleymani Ahooie

  DOI：10.1016/j.molliq.2022.120625

  日期：2022.12

  template-free ionic carbon nitride nanotubes (K-g-C3N4) were created via thermal polymerizing and aqueous alkaline liquid-phase exfoliation. The characterization of alkaline K-doped ionic graphitic carbon nitride (K-g-C3N4) was determined by FT-IR, SEM, EDS, and TGA analysis. A simple, facile, and efficient synthesis of 2-amino-5-alkylidene-thiazol-4-ones derivatives via a multicomponent reaction of various

  石墨氮化碳 (gC 3 N 4 ) 具有类似于石墨的层状结构，并在有机转化中提供令人兴奋和独特的支持。使用边缘功能化的石墨氮化碳通过掺杂各种官能团并将其转变为另一种形态已成为近十年来关注的焦点。具有弱碱性的富氮结构；因此，它必须通过各种功能化来改善其性能。在此，首次通过热聚合和水性碱性液相剥离制备了无模板离子氮化碳纳米管（KgC 3 N 4 ）。碱性K掺杂离子石墨碳氮化碳（KgC 3N 4 ) 通过FT-IR、SEM、EDS和TGA分析确定。 使用可重复使用的 KgC 3 N 4作为绿色催化剂，通过各种醛、胺和罗丹宁在乙醇中的多组分反应，简单、简便、高效地合成 2-氨基-5-亚烷基-噻唑-4-酮衍生物。发达。通过用罗丹明改变醛和胺的结构来探索反应范围。各种 2-氨基-5-亚烷基-噻唑-4-酮在 60-180 分钟内的产率范围在 65% 和 96% 之间。由于 KgC 3 N 4的异质性，催
• An Efficient One-pot Synthesis of 2-Amino-5-arylidenethiazol-4-ones Catalyzed by MgO Nanoparticles
  作者：Narges Shariati、Robabeh Baharfar

  DOI：10.1002/jccs.201300425

  日期：2014.3

  AbstractA mild and efficient protocol for the synthesis of 2‐amino‐5‐arylidene‐1,3‐thiazol‐4(5H)‐ones is reported by three component reaction of aldehydes, rhodanine and secondary amines in the presence of magnesium oxide nanoparticles as heterogeneous nanocatalyst in good yields and short reaction times.
• Omar, M. T.; Kasem, M. A., Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1413 - 1415
  作者：Omar, M. T.、Kasem, M. A.

  DOI：——

  日期：——
• Reactions of N,N-Disubstituted 5-Arylmethylidene-2-amino-thiazol-4(5H)-ones with CH Acids
  作者：Kamal A. Kandeel、Ali M. Youssef、Hany M. El-Bestawy、Mohamed T. Omar

  DOI：10.1007/s007060200092

  日期：2002.9.1

  N,N-Disubstituted 5-arylmethylidene-2-aminothiazol-4(5H)-ones reacted with diethyl malonate, ethyl benzoylacetate, acetylacetone, or cyclopentadiene in refluxing toluene and in presence of powdered sodium to give the respective 5-arylmethylidene-2'-amino-2,5'-bithiazolylidene-4,4'-dione derivatives in moderate yields. 5-Benzylidene-2-morpholin-4-yl-2-thiazol-4(5H)-one reacted with malononitrile in toluene and in presence of powdered sodium under mild conditions to afford the 1:1 adduct, benzylmalononitrile, and 2-morpholin-4-yl-2-thiazol-4(5H)-one. However, similar treatment of 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-one with malononitrile yielded the 2,5'-bithiazolylidene-4,4'-dione derivative together with 4-methoxyphenylmethylidene malononitrile. Treatment of 5-benzylidene- and 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-ones with 3-phenyl-4-oxo-2-thioxo-1,3-thiazolidine in refluxing toluene and in presence of powdered sodium produced 5-arylmethylidene-3-phenyl-4-oxo-2-thioxo-1,3-thiazolidines in good yields. The structures of all products were deduced from microanalytical and spectroscopic data, mechanistic details are discussed.
• Kandeel, Kamal A.; Youssef, Ali M.; El-Bestawy, Hany M., Journal of Chemical Research, Miniprint, 2003, # 11, p. 1129 - 1140
  作者：Kandeel, Kamal A.、Youssef, Ali M.、El-Bestawy, Hany M.、Omar, Mohamed T.

  DOI：——

  日期：——