1-benzyl-5'-(3-fluorophenyl)-1H-spiro[piperidine-4,6'-pyrrolo[3,4-b]pyrrol]-4'(5'H)-one | 1038772-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-benzyl-5'-(3-fluorophenyl)-1H-spiro[piperidine-4,6'-pyrrolo[3,4-b]pyrrol]-4'(5'H)-one
• 英文别名: 1-benzyl-5'-(3-fluorophenyl)-1'H-spiro[piperidine-4,6'-pyrrolo[3,4-b]pyrrol]-4'(5'H)-one；1'-benzyl-5-(3-fluorophenyl)spiro[1H-pyrrolo[3,4-b]pyrrole-6,4'-piperidine]-4-one
• CAS: 1038772-11-0
• 化学式: C₂₃H₂₂FN₃O
• 分子量: 375.446
• InChiKey: BWRPRVJUGPDGGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  39.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-benzyl-1-(3-fluorophenyl)-1,8-diazaspiro[4.5]decane-2,4-dione 、 氨基乙醛缩二甲醇 在 甲苯 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以to yield 1-benzyl-5′-(3-fluorophenyl)-1′H-spiro[piperidine-4,6′-pyrrolo[3,4-b]pyrrol]-4′(5′H)-one的产率得到1-benzyl-5'-(3-fluorophenyl)-1H-spiro[piperidine-4,6'-pyrrolo[3,4-b]pyrrol]-4'(5'H)-one
  参考文献：
  名称：

  BICYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

  摘要：

  本发明涉及公式（I）的双环螺环吡啶化合物，其为β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病中有用。本发明还涉及包含这些化合物的制药组合物以及在治疗β-分泌酶酶参与的这些疾病中使用这些化合物和组合物的用途。

  公开号：

  US20100076004A1

文献信息

• BICYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Stauffer Shaun R.

  公开号：US20100076004A1

  公开（公告）日：2010-03-25

  The present invention is directed to bicyclic spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及公式（I）的双环螺环吡啶化合物，其为β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病中有用。本发明还涉及包含这些化合物的制药组合物以及在治疗β-分泌酶酶参与的这些疾病中使用这些化合物和组合物的用途。
• WO2008/85509
  申请人：——

  公开号：——

  公开（公告）日：——
• US8377954B2
  申请人：——

  公开号：US8377954B2

  公开（公告）日：2013-02-19
• [EN] BICYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA BÊTA-SÉCRÉTASE DE SPIROPIPÉRIDINE BI-CYCLIQUE DESTINÉS AU TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2008085509A1

  公开（公告）日：2008-07-17

  [EN] The present invention is directed to bicyclic spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
  [FR] La présente invention concerne des composés de spiropipéridine bi-cyclique de formule (I) qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles pour le traitement de maladies dans lesquelles l'enzyme de bêta-sécrétase est impliquée, comme la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions pour le traitement de maladies dans lesquelles l'enzyme de bêta-sécrétase est impliquée.
• Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
  申请人：Stauffer Shaun R.

  公开号：US08377954B2

  公开（公告）日：2013-02-19

  The present invention is directed to bicyclic spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及公式（I）的双环螺内酯哌啶类化合物，它们是β-分泌酶酶的抑制剂，可用于治疗β-分泌酶酶参与的疾病，如阿尔茨海默病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在治疗β-分泌酶酶参与的疾病方面的用途。