trimethylsilyl iodoacetate | 55030-41-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: trimethylsilyl iodoacetate
• 英文别名: Iodessigsaeure-trimethylsilylester；Acetic acid, iodo-, trimethylsilyl ester；trimethylsilyl 2-iodoacetate
• CAS: 55030-41-6
• 化学式: C₅H₁₁IO₂Si
• 分子量: 258.131
• InChiKey: YKELGBGDJRLOFU-UHFFFAOYSA-N

物化性质

• 沸点：
  166.5±23.0 °C(Predicted)
• 密度：
  1.526±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  trimethylsilyl iodoacetate 、 N-甲基-1-(三乙氧基硅烷基)甲胺 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以32%的产率得到2,2-diethoxy-4-methyl-1-oxa-4-aza-2-silacyclohexane-6-one
  参考文献：
  名称：

  N-methyI-N-(triethoxysilylmethyl) andN-methyl-N-(silatran-1-ylmethyl) substituted glycine and alanine

  摘要：

  Organosilicon derivatives of glycine, alpha- and beta-alanine, and alpha-methylalanine were prepared by the reaction of methyl esters of alpha- and beta-halocarboxylic acids with N-methyl-aminomethyltriethoxysilane in the presence of triethylamine. The compounds synthesized were converted into the corresponding N-silatran-1-ylmethyl derivatives. Trimethyl-silyliodoacetate reacts with N-methylaminomethyltrietoxysilane to give 2,2-diethoxy-4-methyl-1-oxa-4-aza-2-silacyclohexane-6-one. Its reaction with triethanolamine leads to N-methyl-N-(silatran-1-ylmethyl)glycine.

  DOI：

  10.1007/bf00702147
• 作为产物：
  描述：

  N,O-双三甲硅基乙酰胺 、 碘乙酸 生成 trimethylsilyl iodoacetate
  参考文献：
  名称：

  Functional Group Interactions in the Mass Spectra of Trimethylsilyl Derivatives of Halo Acids and Halo Alcohols

  摘要：

  DOI：

  10.1021/jo00837a628

文献信息

• Functional Group Interactions in the Mass Spectra of Trimethylsilyl Derivatives of Halo Acids and Halo Alcohols
  作者：Edward White、James McCloskey

  DOI：10.1021/jo00837a628

  日期：1970.12
• N-methyI-N-(triethoxysilylmethyl) andN-methyl-N-(silatran-1-ylmethyl) substituted glycine and alanine
  作者：N. F. Lazareva、V. P. Baryshok、M. G. Voronkov

  DOI：10.1007/bf00702147

  日期：1995.2

  Organosilicon derivatives of glycine, alpha- and beta-alanine, and alpha-methylalanine were prepared by the reaction of methyl esters of alpha- and beta-halocarboxylic acids with N-methyl-aminomethyltriethoxysilane in the presence of triethylamine. The compounds synthesized were converted into the corresponding N-silatran-1-ylmethyl derivatives. Trimethyl-silyliodoacetate reacts with N-methylaminomethyltrietoxysilane to give 2,2-diethoxy-4-methyl-1-oxa-4-aza-2-silacyclohexane-6-one. Its reaction with triethanolamine leads to N-methyl-N-(silatran-1-ylmethyl)glycine.