2-hydroxyethyl selenol | 60718-59-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-hydroxyethyl selenol
• 英文别名: 2-hydroxyethaneselenol；2-selanylethanol；2-selanyl-1-ethanol；2-Hydroxy-aethyl-selen-mercaptan；2-Selanylethan-1-ol
• CAS: 60718-59-4
• 化学式: C₂H₆OSe
• 分子量: 125.029
• InChiKey: OYMYHYJAYQACBR-UHFFFAOYSA-N

物化性质

• 沸点：
  75 °C(Press: 16 Torr)
• 密度：
  1.5890 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴代十四烷 、 2-hydroxyethyl selenol 以 乙醇 、 水 为溶剂， 反应 0.5h， 以46%的产率得到2-Tetradecylselanylethanol
  参考文献：
  名称：

  [EN] LIPID-LIKE NANOCOMPLEXES AND USES THEREOF
  [FR] NANOCOMPLEXES DE TYPE LIPIDE ET LEURS UTILISATIONS

  摘要：

  以下是公式（I）的化合物：（I），其中在此定义了变量A、B、X、W、V、R1-R5和m的每个变量。还公开了含有纳米复合物的药物组合物，其中纳米复合物由化合物之一和蛋白质、核酸或小分子形成；以及使用其中一种药物组合物治疗医疗状况的方法。

  公开号：

  WO2019152848A1
• 作为产物：
  描述：

  1,2-bis(2-hydroxyethyl)diselenide 在 氢氧化钾 、 一水合肼 作用下， 反应 2.5h， 以47%的产率得到2-hydroxyethyl selenol
  参考文献：
  名称：

  Chalcogen-containing analogs of ethylene glycol and its derivatives

  摘要：

  Ethylene chlorohydrin when reacted with elemental chalcogens or dimethyl dichalcogenides in the hydrazine hydrate-alkali system forms chalcogen-containing analogs of ethylene glycol and its derivatives (dichalcogenated beta-diglycols, chalcogenated ethanols, and chalcogenated methyl cellosolves).

  DOI：

  10.1134/s1070363208040166

文献信息

• 2-(Pyrazol-4-yl)-1,3-oxaselenolanes from Pyrazole Сarbaldehydes and 2-Selanyl-1-ethanol
  作者：Lyubov K. Papernaya、Alexandra A. Shatrova、Ekaterina P. Levanova、Alexandr I. Albanov、Lyudmila V. Klyba、Elena V. Rudyakova、Galina G. Levkovskaya

  DOI：10.1002/hc.21200

  日期：2015.1

  Pyrazole carbaldehydes react with 2-selanyl-1-ethanol at room temperature in the presence of trimethylchlorosilane followed by treatment with triethyl amine to afford the corresponding 2-(pyrazol-4-yl)-1,3-oxaselenolanes. The structure of the novel compounds was confirmed by IR, 13C, 1H, 15N, and 77Se NMR spectroscopy.

  吡唑甲醛在室温下在三甲基氯硅烷存在下与 2-selanyl-1-乙醇反应，然后用三乙胺处理，得到相应的 2-(pyrazol-4-yl)-1,3-oxaselenolanes。新化合物的结构经IR、13C、1H、15N和77Se NMR光谱确证。
• Diastereomers of Nucleoside 3'-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s
  作者：Wojciech J. Stec、Andrzej Grajkowski、Anna Kobylanska、Boleslaw Karwowski、Maria Koziolkiewicz、Konrad Misiura、Andrzej Okruszek、Andrzej Wilk、Piotr Guga、Malgorzata Boczkowska

  DOI：10.1021/ja00154a001

  日期：1995.12

  Diastereomerically pure 5'-O-DMT-nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholanes) (3) and their oxathiaphospholane ring-substituted analogues (20) were used for the synthesis of stereoregular oligo(nucleoside phosphorothioate)s (S-Oligos). The oxathiaphospholane ring-opening condensation requires the presence of strong organic base, preferably DBU. The yield of a single coupling step is ca. 95% and resulting S-Oligos are free of nucleobase- and sugar-phosphorothioate backbone modifications. The diastereomeric purity of products was estimated on the basis of diastereoselective degradation with Nuclease P1 and a mixture of snake venom phosphodiesterase and Serratia marcescens endonuclease. Thermal dissociation studies of heteroduplexes S-Oligos/DNA and S-Oligos/RNA showed that their stability is stereochemistry- and sequence-dependent.
• Kurbanov, S. B.; Mamedov, E. Sh.; Mishiev, R. D., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 5, p. 812 - 816
  作者：Kurbanov, S. B.、Mamedov, E. Sh.、Mishiev, R. D.、Gusiev, N. Kh.、Agaeva, E. A.

  DOI：——

  日期：——
• [EN] LIPID-LIKE NANOCOMPLEXES AND USES THEREOF<br/>[FR] NANOCOMPLEXES DE TYPE LIPIDE ET LEURS UTILISATIONS
  申请人：TUFTS COLLEGE

  公开号：WO2019152848A1

  公开（公告）日：2019-08-08

  Disclosed are compounds of formula (I) below: (I), wherein each of the variables A, B, X, W, V, R1-R5, and m is defined herein. Also disclosed are pharmaceutical compositions containing a nanocomplex, wherein the nanocomplex is formed of one of the compounds, and a protein, a nucleic acid, or a small molecule; and methods of treating a medical condition with one of the pharmaceutical compositions.

  以下是公式（I）的化合物：（I），其中在此定义了变量A、B、X、W、V、R1-R5和m的每个变量。还公开了含有纳米复合物的药物组合物，其中纳米复合物由化合物之一和蛋白质、核酸或小分子形成；以及使用其中一种药物组合物治疗医疗状况的方法。
• Chalcogen-containing analogs of ethylene glycol and its derivatives
  作者：V. Yu. Vshivtsev、E. P. Levanova、V. A. Grabel’nykh、E. A. Sukhomazova、A. I. Albanov、L. V. Klyba、E. R. Zhanchipova、N. V. Russavskaya、N. A. Kochervin

  DOI：10.1134/s1070363208040166

  日期：2008.4

  Ethylene chlorohydrin when reacted with elemental chalcogens or dimethyl dichalcogenides in the hydrazine hydrate-alkali system forms chalcogen-containing analogs of ethylene glycol and its derivatives (dichalcogenated beta-diglycols, chalcogenated ethanols, and chalcogenated methyl cellosolves).