2-哌嗪甲基乙酸酯 | 148227-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-哌嗪甲基乙酸酯
• 英文名称: Piperazin-2-ylmethyl Acetate
• CAS: 148227-95-6
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: IKDSAXJOPDPJSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Heterocyclic derivatives
  申请人：——

  公开号：US20030195203A1

  公开（公告）日：2003-10-16

  The invention relates to heterocyclic derivatives of formula (I) A—B—X 1 —T 1 (R 2 )—L 1 —T 2 (R 3 )—X 2 —Q  (I) or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

  本发明涉及公式(I)A-B-X1-T1(R2)-L1-T2(R3)-X2-Q的杂环衍生物或其药学上可接受的盐，具有抗血栓和抗凝血特性，因此在人类或动物的治疗方法中有用。本发明还涉及制备这些杂环衍生物的过程，含有它们的制药组合物以及它们用于制造用于产生抗血栓或抗凝血效应的药物的用途。
• Heteroaryl-phenyl derivatives as factor xa inhibitors for use as antithrombotic and anticoagulant agents
  申请人：AstraZeneca AB

  公开号：EP1358909A1

  公开（公告）日：2003-11-05

  The invention relates to heterocyclic derivatives of formula (I)         A-B-X1-T1(R2)-L1-T2(R3)-X2-Q     (I) where the variables are defined in the specification, or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

  本发明涉及式 (I) 的杂环衍生物 A-B-X1-T1(R2)-L1-T2(R3)-X2-Q (I) 或其药学上可接受的盐，它们具有抗血栓和抗凝血特性，因此可用于人类或动物的治疗方法。本发明还涉及杂环衍生物的制备工艺、含有杂环衍生物的药物组合物以及它们在制造用于产生抗血栓或抗凝血作用的药物中的用途。
• HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa
  申请人：ZENECA LIMITED

  公开号：EP0937048A1

  公开（公告）日：1999-08-25
• US6300330B1
  申请人：——

  公开号：US6300330B1

  公开（公告）日：2001-10-09
• US6936610B2
  申请人：——

  公开号：US6936610B2

  公开（公告）日：2005-08-30