3-[2-(Dimethylamino)ethyl]-1,1-diethylurea | 1239906-72-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-[2-(Dimethylamino)ethyl]-1,1-diethylurea
• CAS: 1239906-72-9
• 化学式: C₉H₂₁N₃O
• 分子量: 187.285
• InChiKey: UUASHYLYDGHFEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-二乙基氯甲酰胺 、 N,N-二甲基乙二胺 以 1,4-二氧六环 为溶剂， 以80%的产率得到3-[2-(Dimethylamino)ethyl]-1,1-diethylurea
  参考文献：
  名称：

  Perveen, Shahnaz; Fatima, Nasreen; Khan, Khalid Mohammed, Journal of the Chemical Society of Pakistan, 2010, vol. 32, # 3, p. 338 - 343

  摘要：

  DOI：

文献信息

• Perveen, Shahnaz; Fatima, Nasreen; Khan, Khalid Mohammed, Journal of the Chemical Society of Pakistan, 2010, vol. 32, # 3, p. 338 - 343
  作者：Perveen, Shahnaz、Fatima, Nasreen、Khan, Khalid Mohammed、Khan, Ajmal、Ali, Muhammad、Choudhary, Muhammad Iqbal

  DOI：——

  日期：——
• Antidepressant activity of carbamates and urea derivatives
  作者：Shahnaz Perveen、Nasreen Fatima、Muhammad Aitmaud Khan、Ahsana Dar、Khalid M. Khan、Nighat Afza、Wolfgang Voelter

  DOI：10.1007/s00044-011-9797-8

  日期：2012.9

  Thirteen (13) compounds of N-phenyl-O-alkyl carbamates (1 and 3), N,N-diethyl-N'-alkyl/aryl/phenylpiperazinoureas (4-6, 8-12), N-phenyl-N'-phenylpiperazino/imidazoureas (2, 7), and N-ethyl-(N'-phenylpiperazino) thioureas 13 were synthesized and tested for their antidepressant-like activity in mice. It was found that compound N-phenyl-O-heptyl carbamate 1 and N-phenyl-N'-phenylpiperazinourea 2 showed 32.5 and 27.7% antidepressant activity in the forced swim test in mice, respectively. Considering other carbamates it was found that a decrease in alkyl chain length caused a marked decline in the antidepressant activity. Compounds 1-4 show even higher activities in the forced swim test than the standard phenelzine.