1-trityl-4-(2-cyanoethyl)imidazole | 154312-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-trityl-4-(2-cyanoethyl)imidazole
• 英文别名: 3-[1-(Triphenylmethyl)-1H-imidazol-4-yl]-2-propenenitrile；3-(1-tritylimidazol-4-yl)prop-2-enenitrile
• CAS: 154312-79-5
• 化学式: C₂₅H₁₉N₃
• 分子量: 361.446
• InChiKey: PIYOFQNVWJUYPC-UHFFFAOYSA-N

物化性质

• 沸点：
  548.8±45.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-trityl-4-(2-cyanoethyl)imidazole 在 palladium on activated charcoal lithium aluminium tetrahydride 、 三氯化铝 、 氢气 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 1.0h， 生成 3-(1-三苯甲基-1H-咪唑-4-基)-正丙胺
  参考文献：
  名称：

  [3-(1 H -Imidazol-4-yl)propyl]guanidines containing furoxan moieties

  摘要：

  Synthesis and pharmacological characterisation of a series of products obtained by coupling the H-3-antagonist SKF 91486 through appropriate spacers with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan substructures, devoid of NO-donating properties, are reported. All the products were tested for their H-3-antagonistic and H-2-agonistic properties on electrically-stimulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. The whole series of compounds displayed good H-3-antagonist behaviour and feeble partial H-2-agonist activity. Among furoxan derivatives, the benzenesulfonyl hybrid 28, a good NO-donor, triggered a dual NO-dependent muscle relaxation and H3-antagonistic effect on guinea-pig intestine. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00651-x
• 作为产物：
  描述：

  1-三苯甲基-1H-咪唑-4-甲醇 在 manganese(IV) oxide 、 sodium amide 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 21.0h， 生成 1-trityl-4-(2-cyanoethyl)imidazole
  参考文献：
  名称：

  Adger, Brian M.; Surtees, John, Synthetic Communications, 1987, vol. 17, # 2, p. 223 - 228

  摘要：

  DOI：

文献信息

• [3-(1 H -Imidazol-4-yl)propyl]guanidines containing furoxan moieties
  作者：Massimo Bertinaria、Antonella Di Stilo、Paolo Tosco、Giovanni Sorba、Enzo Poli、Cristina Pozzoli、Gabriella Coruzzi、Roberta Fruttero、Alberto Gasco

  DOI：10.1016/s0968-0896(02)00651-x

  日期：2003.4

  Synthesis and pharmacological characterisation of a series of products obtained by coupling the H-3-antagonist SKF 91486 through appropriate spacers with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan substructures, devoid of NO-donating properties, are reported. All the products were tested for their H-3-antagonistic and H-2-agonistic properties on electrically-stimulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. The whole series of compounds displayed good H-3-antagonist behaviour and feeble partial H-2-agonist activity. Among furoxan derivatives, the benzenesulfonyl hybrid 28, a good NO-donor, triggered a dual NO-dependent muscle relaxation and H3-antagonistic effect on guinea-pig intestine. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Adger, Brian M.; Surtees, John, Synthetic Communications, 1987, vol. 17, # 2, p. 223 - 228
  作者：Adger, Brian M.、Surtees, John

  DOI：——

  日期：——
• H3 receptor ligands: new imidazole H3-antagonists endowed with NO-donor properties
  作者：Massimo Bertinaria

  DOI：10.1016/s0014-827x(03)00023-5

  日期：2003.3

  Synthesis and pharmacological properties of a group of compounds obtained by coupling the H(3)-antagonist SKF 91486 with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan analogues, devoid of NO-donating properties, are reported. All the products were tested for their H(3)-antagonistic and H(2)-agonistic properties on electrically-simulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. All the synthesised compounds displayed good H(3)-antagonistic properties (pA(2) range 7.02-8.49) while behaving only as weak partial H(2)-agonists. Derivative 28, the best NO-donor of the series, was able to trigger a dual NO-dependent muscle relaxation and H(3)-antagonistic effect on guinea-pig illeum.