N-(2-propenamidoethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide | 1253963-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: N-(2-propenamidoethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide
• 英文别名: N-(2-propenamidoethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide；N-(2-acrylamidoethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide；5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-(prop-2-enoylamino)ethyl]pentanamide
• CAS: 1253963-38-0
• 化学式: C₁₅H₂₄N₄O₃S
• 分子量: 340.447
• InChiKey: FXBVCLLVNIKYMC-MJVIPROJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (+)生物素-N-琥珀酰亚胺基酯 、 N-(2-氨基乙基)丙烯酰胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 N-(2-propenamidoethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide
  参考文献：
  名称：

  通过“Click Thiol”硫醇-迈克尔型加成和与 CuAAC“Click Huisgen”组合合成单缀合和多缀合寡核苷酸

  摘要：

  通过从单-硫代己基-或四-硫代己基-寡核苷酸开始并用丙烯酰胺衍生物（碳水化合物、二茂铁、生物素、荧光染料、脱氧胆酸）处理，可以有效合成单缀合和多缀合寡核苷酸。硫醇迈克尔型添加 (TMTA) 发生在寡核苷酸从固体支持物脱保护和释放期间，因此不需要额外的缀合时间。铜催化的叠氮化物-炔环加成 (CuAAC) 在固体载体上然后是 TMTA 或 TMTA 然后是溶液中的 CuAAC 的顺序组合允许合成几种用两种不同生物分子装饰的寡核苷酸。

  DOI：

  10.1002/ejoc.201201311

文献信息

• POLYMERS AND NANOGEL MATERIALS AND METHODS FOR MAKING AND USING THE SAME
  申请人：Johnson & Johnson Vision Care Inc.

  公开号：EP2855544A2

  公开（公告）日：2015-04-08
• US9726906B2
  申请人：——

  公开号：US9726906B2

  公开（公告）日：2017-08-08
• [EN] POLYMERS AND NANOGEL MATERIALS AND METHODS FOR MAKING AND USING THE SAME<br/>[FR] POLYMÈRES ET MATÉRIAUX DE TYPE NANO-GEL ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2013176886A2

  公开（公告）日：2013-11-28

  Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g/mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment islocated on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel. The polymers may be incorporated into a formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post-formation.
• Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol-Michael-Type Additions and by Combination with CuAAC “Click Huisgen”
  作者：Albert Meyer、Jean-Jacques Vasseur、François Morvan

  DOI：10.1002/ejoc.201201311

  日期：2013.1

  Monoconjugated and multiply conjugated oligonucleotides were efficiently synthesized by starting from mono-thiohexyl- or tetra-thiohexyl-oligonucleotides and treatment with acrylamide derivatives (carbohydrates, ferrocene, biotin, fluorescent dyes, deoxycholic acid). The thiol Michael-type additions (TMTAs) occurred during the deprotection and release of the oligonucleotides from the solid support

  通过从单-硫代己基-或四-硫代己基-寡核苷酸开始并用丙烯酰胺衍生物（碳水化合物、二茂铁、生物素、荧光染料、脱氧胆酸）处理，可以有效合成单缀合和多缀合寡核苷酸。硫醇迈克尔型添加 (TMTA) 发生在寡核苷酸从固体支持物脱保护和释放期间，因此不需要额外的缀合时间。铜催化的叠氮化物-炔环加成 (CuAAC) 在固体载体上然后是 TMTA 或 TMTA 然后是溶液中的 CuAAC 的顺序组合允许合成几种用两种不同生物分子装饰的寡核苷酸。