thiophene-2,5-dicarbohydrazide | 14282-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: thiophene-2,5-dicarbohydrazide
• CAS: 14282-55-4
• 化学式: C₆H₈N₄O₂S
• mdl: MFCD03268130
• 分子量: 200.221
• InChiKey: OZOUBFCLGNGYTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  thiophene-2,5-dicarbohydrazide 在 三氯氧磷 作用下， 以 吡啶 为溶剂， 反应 504.0h， 生成 2,5-bis{5-[5-(4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thienyl]-1,3,4-oxadiazol-2-yl}thiophene
  参考文献：
  名称：

  Structure-Property Relationships in Mixed Oligoheterocycles Based on End-Capped Oligothiophenes

  摘要：

  DOI：

  10.1002/(sici)1099-0690(200002)2000:3<425::aid-ejoc425>3.0.co;2-z
• 作为产物：
  描述：

  diethyl thiophene-2,5-dicarboxylate 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 thiophene-2,5-dicarbohydrazide
  参考文献：
  名称：

  Zn2+ion responsive fluorescent chemosensor probe of Thiophene-diocarbohydrazide derivatives

  摘要：

  DOI：

  10.1016/j.ica.2020.120149

文献信息

• Double Schiff base from thiophene-2,5-dicarboxylic acid as an “off–on–off” fluorescence sensor for the sequential detection of In³⁺ and PPi
  作者：Yujing Xing、Zhihua Liu、Yuankang Xu、Hanyu Wang、Linlin Li、Bing Li、Xiaofeng Yang、Meishan Pei、Guangyou Zhang

  DOI：10.1039/d0nj03076g

  日期：——

  A double Schiff base T as acceptor for metal ions derived from thiophene-2,5-dicarboxylic acid was designed and synthesized, and showed a high selectivity for In³⁺ in a DMF/H₂O buffer solution.

  设计并合成了一种以噻吩-2,5-二甲酸为基础的双Schiff碱T，作为金属离子的受体，并在DMF/H2O缓冲溶液中表现出对In3+的高选择性。
• Synthesis and Optoelectronic Properties of Symmetrical Thiophene Based 2,5-disubstiuted 1,3,4-oxadiazoles: Highly Fluorescent Materials for OLED Applications
  作者：Shridhar I. Panchamukhi、Ningaraddi Belavagi、Mohammed Hussain Rabinal、Imitiyaz Ahmed Khazi

  DOI：10.1007/s10895-011-0838-y

  日期：2011.7

  carried out on these compounds and found that they exhibit good fluorescent properties with high quantum yield. Symmetrical 2,5-disubstituted thiophene derivatives containing the 1,3,4-oxadiazole moiety were synthesized from the corresponding thiophene 2,5-dicarboxylic acid. The Photophysical and electrochemical properties revealed that these compounds are good fluorescent materials with high quantum

  以噻吩-2,5, 二羧酸为起始原料，采用方便简单的合成方案，合成了对称的 2,5-二取代噻吩衍生物，该衍生物含有 1,3,4-恶二唑部分，具有不同的芳族取代基。这些目标分子的结构是通过它们的分析和光谱数据确定的。对这些化合物进行了光物理和电化学研究，发现它们具有良好的荧光性能和高量子产率。 含有 1,3,4-恶二唑部分的对称 2,5-二取代噻吩衍生物由相应的噻吩 2,5-二羧酸合成。光物理和电化学特性表明，这些化合物是用于 OLED 应用的具有高量子产率的良好荧光材料。
• AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
  申请人：Miyaji Katsuaki

  公开号：US20090131659A1

  公开（公告）日：2009-05-21

  The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective. A compound represented by the formula (1): wherein A, B, R 1 , L 1 , R 2 , L 2 , L 3 , Y, L 4 , R 3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  本发明提供了化合物，用于预防、治疗或缓解激活血小板生成素受体对其有效的疾病。其中一种化合物的表示式为（1）：其中A、B、R1、L1、R2、L2、L3、Y、L4、R3和X的定义与描述中相同，以及该化合物的互变异构体、前药或药物可接受的盐或其溶剂化物。
• Thiophene-derived “off-on-off” fluorescence chemosensors for the detection of zinc and phytate ions sequentially
  作者：Yujing Xing、Chaoxia Guo、Xiaochuan Guo、Yuanying Liu、Kehui Wei、Mingyi Kang、Xiaofeng Yang、Meishan Pei、Guangyou Zhang

  DOI：10.1016/j.jphotochem.2023.114797

  日期：2023.8

  need for pretreatment of the tested solution, which was currently an excellent fluorescence platform for the detection of phytate ions. The recognition process of target ions was explained in detail through spectral measurement and MS spectrum titration. Furthermore, the theoretical calculations were performed to provide reasonable evidence for excellent behavior of sensors. Moreover, the quantitative

  本研究设计并合成了基于噻吩的小分子传感器R和Q ，它们可以根据“关-开-关”荧光依次监测水溶液中的Zn 2+和植酸根离子。与其他报道的传感器相比，这两种传感器都表现出对目标离子的超灵敏响应，尤其是对植酸盐离子的响应，具有低检测限 (3.04 × 10 -10 M ) 和快速检测速率 (<10 s)。更重要的是，乙二氧基修饰的复合物Q -Zn 2+对植酸根离子的选择性高于 PPi 和 PO 4 3−，无需对被测溶液进行预处理，是目前检测植酸根离子的优良荧光平台。通过光谱测量和质谱滴定详细说明了目标离子的识别过程。此外，还进行了理论计算，为传感器的出色性能提供了合理的证据。此外，对水样中Zn 2+和植酸根离子的定量检测有力地支持了这两种传感器的应用潜力。
• Controlling Ion-Sensing Specificity of <i>N</i>-Amidothioureas: From Anion-Selective Sensors to Highly Zn²⁺-Selective Sensors by Tuning Electronic Effects
  作者：Hua-Long Chen、Zhi-Fo Guo、Zhong-lin Lu

  DOI：10.1021/ol302313x

  日期：2012.10.5

  N-Amidothioureas bearing nitro groups showed different sensitivities to various anions, while those with methoxy moieties exhibited the sensitive and selective fluorescence turn-on property for Zn2+ in aqueous solution and in cells. N-Amidothioureas can therefore be adjusted from anion-selective sensors to Zn2+-selective sensors by varying the electronic effects of their substituents.