Quin, Louis D.; Gordon, Michael D.; MacDiarmid, Joan E., Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 1041 - 1044
作者:Quin, Louis D.、Gordon, Michael D.、MacDiarmid, Joan E.
DOI:——
日期:——
QUIN, L. D.;GORDON, M. D.;MACDIARMID, J. E., J. HETEROCYCL. CHEM., 1982, 19, N 5, 1041-1044
作者:QUIN, L. D.、GORDON, M. D.、MACDIARMID, J. E.
DOI:——
日期:——
Efficient Synthesis of Thiopyrans Using a Sulfur-Enabled Anionic Cascade
作者:Fang Li、David Calabrese、Matthew Brichacek、Ivy Lin、Jon T. Njardarson
DOI:10.1002/anie.201108261
日期:2012.2.20
The fifth element: An efficient new synthetic method for accessing 3,6‐dihydro‐2H‐thiopyrans 1 in one pot has been developed. This method employs an anioniccascade, which is triggered by the addition of a vinyl nucleophile to a carbonyl group followed by S to O thiophosphate migration and an intramolecular thiolate displacement. The scope is demonstrated for a range of ketone and ester substrates
第五要素:开发了一种有效的新型合成方法,可在一锅中获得3,6-dihydro-2 H - thiopyrans 1。该方法采用阴离子级联,其通过将乙烯基亲核试剂加到羰基上,然后硫代磷酸酯从S到O的迁移和分子内硫醇盐的置换来触发。该范围适用于各种酮和酯底物。