3-[(1-Benzylpiperidin-4-yl)oxy-(4-chlorophenyl)methyl]-2-chloropyridine | 1246289-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[(1-Benzylpiperidin-4-yl)oxy-(4-chlorophenyl)methyl]-2-chloropyridine
• 英文别名: 3-[(1-benzylpiperidin-4-yl)oxy-(4-chlorophenyl)methyl]-2-chloropyridine
• CAS: 1246289-44-0
• 化学式: C₂₄H₂₄Cl₂N₂O
• 分子量: 427.373
• InChiKey: CLIUILILIGVGRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chlorophenyl-2-chloropyrid-3-ylmethanol 、 1-苄基-4-羟基哌啶 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以90%的产率得到3-[(1-Benzylpiperidin-4-yl)oxy-(4-chlorophenyl)methyl]-2-chloropyridine
  参考文献：
  名称：

  Fatty acid amide hydrolase inhibitors. 2. Novel synthesis of sterically hindered azabenzhydryl ethers and an improved synthesis of VER-156084

  摘要：

  We report an improved synthesis of the fatty acid amide hydrolase (FAAH) inhibitor VER-156084. The key step is a novel, environmentally benign etherification to form an unusual, highly hindered azabenzhydryl ether. The method is applied to a variety of primary and secondary alcohols. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.136

文献信息

• Fatty acid amide hydrolase inhibitors. 2. Novel synthesis of sterically hindered azabenzhydryl ethers and an improved synthesis of VER-156084
  作者：Stephen D. Roughley、Terance Hart

  DOI：10.1016/j.tetlet.2010.07.136

  日期：2010.9

  We report an improved synthesis of the fatty acid amide hydrolase (FAAH) inhibitor VER-156084. The key step is a novel, environmentally benign etherification to form an unusual, highly hindered azabenzhydryl ether. The method is applied to a variety of primary and secondary alcohols. (c) 2010 Elsevier Ltd. All rights reserved.