3-(pyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester | 877168-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(pyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-Butyl 3-(pyridin-2-yloxy)piperidine-1-carboxylate；tert-butyl 3-pyridin-2-yloxypiperidine-1-carboxylate
• CAS: 877168-36-0
• 化学式: C₁₅H₂₂N₂O₃
• 分子量: 278.351
• InChiKey: IHNMPDCWJDHHFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(pyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester 在 potassium carbonate 、 三氟乙酸 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 1-(4-fluorophenyl)-3-[3-(pyridin-2-yloxy)piperidin-1-yl]propan-1-one
  参考文献：
  名称：

  Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

  摘要：

  A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D-4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.060
• 作为产物：
  描述：

  2-溴吡啶 、 N-BOC-3-羟基哌啶 在 sodium hydride 作用下， 以 甲苯 为溶剂， 反应 0.25h， 以90%的产率得到3-(pyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

  摘要：

  A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D-4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.060